STRINGSTRING
myog myog hsp90aa1.1 hsp90aa1.1 en2a en2a hsp70l hsp70l cdk2 cdk2 myf6 myf6 cdkn1ba cdkn1ba shhb shhb nr4a2b nr4a2b pcna pcna cdkn1bb cdkn1bb skp2 skp2 myhz1.1 myhz1.1 hsp70.1 hsp70.1 myf5 myf5 shha shha limk1a limk1a prdm1a prdm1a myod1 myod1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
myogMyogenin. (256 aa)
hsp90aa1.1Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] (725 aa)
en2aHomeobox protein engrailed-2a. (265 aa)
hsp70lNovel protein similar to heat shock cognate 70-kd protein; Belongs to the heat shock protein 70 family. (643 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
myf6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (239 aa)
cdkn1baCyclin-dependent kinase inhibitor 1Ba. (187 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
nr4a2bNuclear receptor subfamily 4, group A, member 2b. (586 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
cdkn1bbCyclin-dependent kinase inhibitor 1b (P27, kip1). (179 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (410 aa)
myhz1.1Myosin, heavy polypeptide 1.1, skeletal muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
hsp70.1Heat shock cognate 70-kd protein, tandem duplicate 1; Belongs to the heat shock protein 70 family. (643 aa)
myf5Myogenic factor. (237 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
limk1aLIM domain kinase 1a. (648 aa)
prdm1aPR domain-containing 1a, with ZNF domain. (776 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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