STRINGSTRING
ptf1a ptf1a isl1 isl1 ela3l ela3l rbpja rbpja hsp70l hsp70l nkx6.1 nkx6.1 ins ins hist2h2l hist2h2l gcga gcga cryaa cryaa prox1a prox1a gcgb gcgb insb insb rbpjl rbpjl X1WHF1_DANRE X1WHF1_DANRE pax6b pax6b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ptf1aPancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. (265 aa)
isl1Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa)
ela3lElastase 3-like; Belongs to the peptidase S1 family. (269 aa)
rbpjaRecombination signal-binding protein for immunoglobulin kappa J region a. (496 aa)
hsp70lNovel protein similar to heat shock cognate 70-kd protein; Belongs to the heat shock protein 70 family. (643 aa)
nkx6.1NK6 homeobox 1. (312 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
hist2h2lHistone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
gcgaGlucagon a. (121 aa)
cryaaCrystallin, alpha A; Belongs to the small heat shock protein (HSP20) family. (173 aa)
prox1aProspero homeobox 1a. (739 aa)
gcgbGlucagon b. (124 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
rbpjlRecombination signal-binding protein for immunoglobulin kappa J region-like. (510 aa)
X1WHF1_DANREHistone H2B; Belongs to the histone H2B family. (124 aa)
pax6bPaired box 6b. (450 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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