STRINGSTRING
tjp1a tjp1a cfl1 cfl1 zgc:101810 zgc:101810 crkl crkl acta1b acta1b ptpn1 ptpn1 actr2a actr2a irs1 irs1 crk crk pxnb pxnb pik3c3 pik3c3 actr2b actr2b cd2ap cd2ap src src iqgap1 iqgap1 trpc6a trpc6a fat1a fat1a nphs2 nphs2 grb2b grb2b fyna fyna cdc42 cdc42 trpc3 trpc3 Dok3 Dok3 cmip cmip pxna pxna actn4 actn4 nphs1 nphs1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tjp1aTight junction protein 1a; Belongs to the MAGUK family. (1689 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
zgc:101810Zgc:101810; Belongs to the actin family. (394 aa)
crklV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (305 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
ptpn1Protein tyrosine phosphatase non-receptor type 1. (350 aa)
actr2aActin-related protein 2-A; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa)
irs1Insulin receptor substrate 1. (1099 aa)
crkV-crk sarcoma virus CT10 oncogene homolog (Avian). (311 aa)
pxnbPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (525 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (878 aa)
actr2bActin-related protein 2-B; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa)
cd2apCD2-associated protein. (657 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
iqgap1IQ motif-containing GTPase-activating protein 1. (1655 aa)
trpc6aTransient receptor potential cation channel, subfamily C, member 6a; Belongs to the transient receptor (TC 1.A.4) family. (874 aa)
fat1aFAT atypical cadherin 1a. (4611 aa)
nphs2NPHS2 stomatin family member, podocin. (406 aa)
grb2bGrowth factor receptor-bound protein 2b. (217 aa)
fynaTyrosine-protein kinase fyna; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in cntn1-mediated signaling (By similarity). Required for convergent extension cell movements during gastrulation, acting with yes via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling. (537 aa)
cdc42Cell division cycle 42. (191 aa)
trpc3Transient receptor potential cation channel, subfamily C, member 3; Belongs to the transient receptor (TC 1.A.4) family. (902 aa)
Dok3IRS-type PTB domain-containing protein. (482 aa)
cmipC-Maf-inducing protein. (724 aa)
pxnaPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (532 aa)
actn4Actinin, alpha 4. (923 aa)
nphs1NPHS1 adhesion molecule, nephrin. (1287 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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