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sdha sdha mcat mcat myod1 myod1 myog myog six1b six1b tnni2a.4 tnni2a.4 ckma ckma mb mb tnnt2c tnnt2c nck2b nck2b bcl11aa bcl11aa ppargc1a ppargc1a nck2a nck2a hdac5 hdac5 myhz1.1 myhz1.1 tead1a tead1a myf5 myf5 chrng chrng runx1 runx1 myl2b myl2b chrne chrne nck1b nck1b tnnt2a tnnt2a mcat-2 mcat-2 hdac11 hdac11 hdac4 hdac4 tnnt1 tnnt1 med13a med13a myl4 myl4 sox6 sox6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sdhaSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (661 aa)
mcatMalonyl CoA:ACP acyltransferase (mitochondrial). (364 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
myogMyogenin. (256 aa)
six1bHomeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa)
tnni2a.4Troponin I type 2a (skeletal, fast), tandem duplicate 4. (176 aa)
ckmaCreatine kinase, muscle a; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
mbMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (147 aa)
tnnt2cTroponin T1, skeletal, slow. (290 aa)
nck2bCytoplasmic protein. (380 aa)
bcl11aaBAF chromatin-remodeling complex subunit BCL11A a. (829 aa)
ppargc1aPeroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (859 aa)
nck2aCytoplasmic protein. (403 aa)
hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1128 aa)
myhz1.1Myosin, heavy polypeptide 1.1, skeletal muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
tead1aTEA domain family member 1a. (422 aa)
myf5Myogenic factor. (237 aa)
chrngCholinergic receptor, nicotinic, gamma. (540 aa)
runx1Runt-related transcription factor. (451 aa)
myl2bMyosin, light polypeptide 2, regulatory, cardiac, slow. (168 aa)
chrneCholinergic receptor, nicotinic, epsilon. (517 aa)
nck1bCytoplasmic protein. (381 aa)
tnnt2aTroponin T type 2a (cardiac). (282 aa)
mcat-2Malonyl CoA:ACP acyltransferase (mitochondrial). (231 aa)
hdac11Histone deacetylase 11. (366 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa)
tnnt1Troponin T type 1 (skeletal, slow). (342 aa)
med13aMediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2197 aa)
myl4Myosin, light chain 4, alkali; atrial, embryonic. (187 aa)
sox6SRY-box transcription factor 6. (816 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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