STRINGSTRING
prkacba prkacba notch1a notch1a prkacaa prkacaa rbpjl rbpjl tgfb1b tgfb1b insb insb pax5 pax5 lrp5 lrp5 atoh1a atoh1a tgfb5 tgfb5 wnt4 wnt4 tmsb4x tmsb4x rbpjb rbpjb prkacbb prkacbb pax2a pax2a cux1b cux1b tgfb1a tgfb1a cebpg cebpg prkacab prkacab ins ins rbpja rbpja tgfb3 tgfb3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
prkacbaProtein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
prkacaaProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa)
rbpjlRecombination signal-binding protein for immunoglobulin kappa J region-like. (510 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
pax5Paired box 5. (396 aa)
lrp5Low density lipoprotein receptor-related protein 5. (1615 aa)
atoh1aAtonal bHLH transcription factor 1a. (292 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
wnt4Protein Wnt-4a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development. (352 aa)
tmsb4xThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
rbpjbRecombination signal-binding protein for immunoglobulin kappa J region b. (491 aa)
prkacbbProtein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
pax2aPaired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa)
cux1bCut-like homeobox 1b. (672 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
cebpgCCAAT/enhancer binding protein (C/EBP), gamma. (163 aa)
prkacabProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
rbpjaRecombination signal-binding protein for immunoglobulin kappa J region a. (496 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (14%) [HD]