node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acta1b | cdh23 | ENSDARP00000058628 | ENSDARP00000026525 | Actin alpha 1, skeletal muscle b. | Cadherin-related 23. | 0.687 |
acta1b | ctnnb1 | ENSDARP00000058628 | ENSDARP00000139205 | Actin alpha 1, skeletal muscle b. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.967 |
acta1b | pcdh15a | ENSDARP00000058628 | ENSDARP00000130788 | Actin alpha 1, skeletal muscle b. | Protocadherin-related 15a. | 0.596 |
acta1b | pcdh15b | ENSDARP00000058628 | ENSDARP00000141906 | Actin alpha 1, skeletal muscle b. | Protocadherin-related 15b. | 0.588 |
acta1b | ush1c | ENSDARP00000058628 | ENSDARP00000104974 | Actin alpha 1, skeletal muscle b. | Usher syndrome 1C (Autosomal recessive, severe). | 0.596 |
cdh23 | acta1b | ENSDARP00000026525 | ENSDARP00000058628 | Cadherin-related 23. | Actin alpha 1, skeletal muscle b. | 0.687 |
cdh23 | ctnnb1 | ENSDARP00000026525 | ENSDARP00000139205 | Cadherin-related 23. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.738 |
cdh23 | pcdh15a | ENSDARP00000026525 | ENSDARP00000130788 | Cadherin-related 23. | Protocadherin-related 15a. | 0.996 |
cdh23 | pcdh15b | ENSDARP00000026525 | ENSDARP00000141906 | Cadherin-related 23. | Protocadherin-related 15b. | 0.996 |
cdh23 | ush1c | ENSDARP00000026525 | ENSDARP00000104974 | Cadherin-related 23. | Usher syndrome 1C (Autosomal recessive, severe). | 0.999 |
ctnnb1 | acta1b | ENSDARP00000139205 | ENSDARP00000058628 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Actin alpha 1, skeletal muscle b. | 0.967 |
ctnnb1 | cdh23 | ENSDARP00000139205 | ENSDARP00000026525 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Cadherin-related 23. | 0.738 |
ctnnb1 | pcdh15a | ENSDARP00000139205 | ENSDARP00000130788 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Protocadherin-related 15a. | 0.441 |
pcdh15a | acta1b | ENSDARP00000130788 | ENSDARP00000058628 | Protocadherin-related 15a. | Actin alpha 1, skeletal muscle b. | 0.596 |
pcdh15a | cdh23 | ENSDARP00000130788 | ENSDARP00000026525 | Protocadherin-related 15a. | Cadherin-related 23. | 0.996 |
pcdh15a | ctnnb1 | ENSDARP00000130788 | ENSDARP00000139205 | Protocadherin-related 15a. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.441 |
pcdh15a | ush1c | ENSDARP00000130788 | ENSDARP00000104974 | Protocadherin-related 15a. | Usher syndrome 1C (Autosomal recessive, severe). | 0.986 |
pcdh15b | acta1b | ENSDARP00000141906 | ENSDARP00000058628 | Protocadherin-related 15b. | Actin alpha 1, skeletal muscle b. | 0.588 |
pcdh15b | cdh23 | ENSDARP00000141906 | ENSDARP00000026525 | Protocadherin-related 15b. | Cadherin-related 23. | 0.996 |
pcdh15b | ush1c | ENSDARP00000141906 | ENSDARP00000104974 | Protocadherin-related 15b. | Usher syndrome 1C (Autosomal recessive, severe). | 0.986 |