STRINGSTRING
ddc ddc nkx2.2a nkx2.2a phox2bb phox2bb etv1 etv1 shha shha htr1aa htr1aa foxa foxa gatb gatb gata2a gata2a lmx1bb lmx1bb tph1a tph1a shhb shhb nkx6.1 nkx6.1 sim1a sim1a gata3 gata3 etv4 etv4 foxa2 foxa2 sim1b sim1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ddcDopa decarboxylase. (480 aa)
nkx2.2aHomeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). (273 aa)
phox2bbPaired-like homeobox 2Bb. (284 aa)
etv1ETS variant transcription factor 1. (476 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
htr1aa5-hydroxytryptamine (serotonin) receptor 1A a. (398 aa)
foxaForkhead box A sequence. (355 aa)
gatbGlutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily. (553 aa)
gata2aGATA-binding protein 2a. (456 aa)
lmx1bbLIM homeobox transcription factor 1, beta 1. (375 aa)
tph1aTryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a. (483 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
nkx6.1NK6 homeobox 1. (312 aa)
sim1aSingle-minded homolog 1-A; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. (745 aa)
gata3Transcription factor GATA-3. (438 aa)
etv4ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. (494 aa)
foxa2Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. (409 aa)
sim1bSIM bHLH transcription factor 1b. (586 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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