STRINGSTRING
itsn1 itsn1 grb2b grb2b X1WCU6_DANRE X1WCU6_DANRE cdc42 cdc42 plek plek fcho1 fcho1 pxdn pxdn tln1 tln1 tln2a tln2a dnm2a dnm2a psen1 psen1 epn1 epn1 efnb3a efnb3a trpm7 trpm7 pik3r5 pik3r5 Fig4b Fig4b tln2b tln2b grip1 grip1 cfl1l cfl1l cfl2 cfl2 amph amph plek2 plek2 calm2a calm2a efnb2a efnb2a msna msna gnaq gnaq cfl1 cfl1 zgc:101810 zgc:101810 efnb1 efnb1 arrb2b arrb2b gsk3ba gsk3ba hsc70 hsc70 dlg4 dlg4 scamp2 scamp2 pfn2l pfn2l arrb2a arrb2a acta1b acta1b efnb3b efnb3b itsn2a itsn2a actr2a actr2a gsk3bb gsk3bb snx1a snx1a cdk5 cdk5 bin1b bin1b efnb2b efnb2b itsn2b itsn2b dnm1b dnm1b eps15 eps15 hspa8 hspa8 dyrk1aa dyrk1aa actr2b actr2b src src snx9a snx9a pfn2 pfn2 pick1 pick1 mtor mtor arrb1 arrb1 pfn1 pfn1 pi4k2a pi4k2a clint1a clint1a synj1 synj1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
itsn1Intersectin 1 (SH3 domain protein). (1722 aa)
grb2bGrowth factor receptor-bound protein 2b. (217 aa)
X1WCU6_DANREProfilin; Belongs to the profilin family. (127 aa)
cdc42Cell division cycle 42. (191 aa)
plekPleckstrin. (352 aa)
fcho1F-BAR domain only protein 1. (1144 aa)
pxdnPeroxidasin. (1460 aa)
tln1Talin 1. (2544 aa)
tln2aTalin 2a. (2543 aa)
dnm2aDynamin 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (860 aa)
psen1Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family. (456 aa)
epn1Epsin 1. (646 aa)
efnb3aEphrin-B3a; Belongs to the ephrin family. (337 aa)
trpm7Transient receptor potential cation channel, subfamily M, member 7. (1787 aa)
pik3r5Phosphoinositide-3-kinase, regulatory subunit 5. (874 aa)
Fig4bUncharacterized protein. (117 aa)
tln2bTalin 2b. (1537 aa)
grip1Glutamate receptor-interacting protein 1. (1143 aa)
cfl1lCofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. (163 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
amphAmphiphysin. (784 aa)
plek2Plek2 protein. (361 aa)
calm2aCalmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
efnb2aEphrin-B2a; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with ephb4 may play a central role in heart morph [...] (332 aa)
msnaMoesin a. (579 aa)
gnaqGuanine nucleotide-binding protein (G protein), q polypeptide. (359 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
zgc:101810Zgc:101810; Belongs to the actin family. (394 aa)
efnb1Ephrin-B1; Belongs to the ephrin family. (341 aa)
arrb2bArrestin, beta 2b. (408 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
hsc70Heat shock cognate 70; Belongs to the heat shock protein 70 family. (647 aa)
dlg4Disks large homolog 4; Plays a role in synapse assembly and function. Plays a role in synaptic plasticity. (707 aa)
scamp2Secretory carrier-associated membrane protein. (326 aa)
pfn2lProfilin; Belongs to the profilin family. (139 aa)
arrb2aArrestin, beta 2a. (406 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
efnb3bEfnb3 protein; Belongs to the ephrin family. (342 aa)
itsn2aIntersectin 2a. (1665 aa)
actr2aActin-related protein 2-A; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa)
gsk3bbGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (419 aa)
snx1aSorting nexin 1a. (659 aa)
cdk5Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
bin1bBridging integrator 1b. (364 aa)
efnb2bEphrin-B2b; Belongs to the ephrin family. (334 aa)
itsn2bIntersectin 2b. (1741 aa)
dnm1bDynamin 1b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (858 aa)
eps15Epidermal growth factor receptor pathway substrate 15. (1039 aa)
hspa8Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] (649 aa)
dyrk1aaDual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A, a. (737 aa)
actr2bActin-related protein 2-B; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
snx9aSorting nexin. (562 aa)
pfn2Profilin; Belongs to the profilin family. (140 aa)
pick1Protein-interacting with prkca 1. (406 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
arrb1Arrestin, beta 1. (418 aa)
pfn1Profilin; Belongs to the profilin family. (141 aa)
pi4k2aPhosphatidylinositol 4-kinase type 2-alpha; Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). (447 aa)
clint1aClathrin interactor 1a. (633 aa)
synj1Synaptojanin 1. (1308 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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