STRINGSTRING
nck1b nck1b scinla scinla kdrl kdrl lck lck scin scin X1WCU6_DANRE X1WCU6_DANRE btk btk fyna fyna LOC569566 LOC569566 rap1b rap1b pfn1 pfn1 rac2 rac2 rabif rabif pfn2 pfn2 nck2a nck2a scinlb scinlb ptenb ptenb fgfr1b fgfr1b ralaa ralaa rasgef1bb rasgef1bb nck2b nck2b flt1 flt1 foxn1 foxn1 cfl1l cfl1l zap70 zap70 cfl2 cfl2 wasa wasa erbb2 erbb2 rho rho fgfr1a fgfr1a rhoab rhoab cfl1 cfl1 gsna gsna tpi1a tpi1a wasb wasb tpi1b tpi1b pfn2l pfn2l rap1aa rap1aa gna12a gna12a gsnb gsnb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nck1bCytoplasmic protein. (381 aa)
scinlaScinderin-like a. (720 aa)
kdrlVascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1301 aa)
lckTyrosine-protein kinase. (503 aa)
scinScinderin. (733 aa)
X1WCU6_DANREProfilin; Belongs to the profilin family. (127 aa)
btkTyrosine-protein kinase. (640 aa)
fynaTyrosine-protein kinase fyna; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in cntn1-mediated signaling (By similarity). Required for convergent extension cell movements during gastrulation, acting with yes via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling. (537 aa)
LOC569566Fibroblast growth factor receptor 1b,-like. (509 aa)
rap1bRas-related protein Rap-1b; Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
pfn1Profilin; Belongs to the profilin family. (141 aa)
rac2Rac family small GTPase 2. (219 aa)
rabifRAB-interacting factor. (132 aa)
pfn2Profilin; Belongs to the profilin family. (140 aa)
nck2aCytoplasmic protein. (403 aa)
scinlbScinderin-like b. (720 aa)
ptenbPhosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa)
fgfr1bFibroblast growth factor receptor. (766 aa)
ralaaV-ral simian leukemia viral oncogene homolog Aa (ras-related). (206 aa)
rasgef1bbRas-GEF domain-containing family member 1B-B; Guanine nucleotide exchange factor (GEF) for Ras family proteins. (475 aa)
nck2bCytoplasmic protein. (380 aa)
flt1Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1272 aa)
foxn1Forkhead box N1. (565 aa)
cfl1lCofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. (163 aa)
zap70Tyrosine-protein kinase. (604 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
wasaWASP actin nucleation-promoting factor a. (630 aa)
erbb2Receptor protein-tyrosine kinase. (1275 aa)
rhoRhodopsin; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). (354 aa)
fgfr1aFibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
gsnaGelsolin a. (729 aa)
tpi1aTriosephosphate isomerase A; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (248 aa)
wasbWASP actin nucleation-promoting factor b. (479 aa)
tpi1bTriosephosphate isomerase B; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (248 aa)
pfn2lProfilin; Belongs to the profilin family. (139 aa)
rap1aaRAP1A, member of RAS oncogene family a. (185 aa)
gna12aGuanine nucleotide-binding protein (G protein) alpha 12a. (385 aa)
gsnbGelsolin b. (728 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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