STRINGSTRING
mgmt mgmt tbx21 tbx21 hsp90b1 hsp90b1 hsp90aa1.1 hsp90aa1.1 ifnphi1 ifnphi1 ptk2ab ptk2ab braf braf nras nras ido1 ido1 egr2b egr2b irf1a irf1a ptenb ptenb ndnl2 ndnl2 foxp3a foxp3a erbb4a erbb4a stat3 stat3 kita kita sox10 sox10 cspg4 cspg4 mtor mtor foxd3 foxd3 crtam crtam ccr7 ccr7 irf5 irf5 irf1b irf1b cd27 cd27
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mgmtO-6-methylguanine-DNA methyltransferase. (192 aa)
tbx21T-box transcription factor 21. (609 aa)
hsp90b1Heat shock protein 90, beta (Grp94), member 1. (793 aa)
hsp90aa1.1Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] (725 aa)
ifnphi1Interferon phi 1. (185 aa)
ptk2abProtein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1050 aa)
brafB-Raf proto-oncogene, serine/threonine kinase. (817 aa)
nrasGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (188 aa)
ido1Indoleamine 2,3-dioxygenase 1. (435 aa)
egr2bEarly growth response protein 2b; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. (412 aa)
irf1aInterferon regulatory factor. (251 aa)
ptenbPhosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa)
ndnl2Necdin-like 2. (260 aa)
foxp3aForkhead box protein. (419 aa)
erbb4aReceptor protein-tyrosine kinase. (1388 aa)
stat3Signal transducer and activator of transcription. (806 aa)
kitaMast/stem cell growth factor receptor kita; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function. Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes. Required for the differentiation of some, but not all, melanocytes. Not essential for hematopoiesis or primordial germ cell development. (981 aa)
sox10HMG-box transcription factor Sox10. (485 aa)
cspg4Chondroitin sulfate proteoglycan 4. (2305 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
foxd3Forkhead box D3. (371 aa)
crtamIg-like domain-containing protein. (436 aa)
ccr7Chemokine (C-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. (385 aa)
irf5Interferon regulatory factor 5. (516 aa)
irf1bInterferon regulatory factor. (287 aa)
cd27CD27 molecule. (248 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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