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pax3a pax3a myod1 myod1 myog myog gli2a gli2a ckmt1 ckmt1 smo smo chrna1 chrna1 neurod2 neurod2 ckbb ckbb ptch1 ptch1 ckma ckma myf6 myf6 atp2a1 atp2a1 pold1 pold1 ckmt2b ckmt2b gli3 gli3 ckmb ckmb ptch2 ptch2 ihhb ihhb mef2ca mef2ca ckmt2a ckmt2a pola1 pola1 myf5 myf5 ENSDARP00000125042 ENSDARP00000125042 shha shha ckba ckba pax7a pax7a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pax3aTranscription factor PAX3. (509 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
myogMyogenin. (256 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
ckmt1Creatine kinase, mitochondrial 1; Belongs to the ATP:guanido phosphotransferase family. (417 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
chrna1Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (456 aa)
neurod2Neurogenic differentiation factor 2; Transcriptional regulator. Appears to mediate neuronal differentiation (By similarity). (363 aa)
ckbbBrain-subtype creatine kinase; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
ptch1Protein patched homolog 1. (1475 aa)
ckmaCreatine kinase, muscle a; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
myf6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (239 aa)
atp2a1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1005 aa)
pold1DNA polymerase. (1105 aa)
ckmt2bCreatine kinase, mitochondrial 2b (sarcomeric); Belongs to the ATP:guanido phosphotransferase family. (413 aa)
gli3GLI family zinc finger 3. (1553 aa)
ckmbCreatine kinase, muscle b; Belongs to the ATP:guanido phosphotransferase family. (380 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
mef2caMyocyte enhancer factor 2ca. (465 aa)
ckmt2aCreatine kinase, mitochondrial 2a (sarcomeric); Belongs to the ATP:guanido phosphotransferase family. (417 aa)
pola1DNA polymerase. (1468 aa)
myf5Myogenic factor. (237 aa)
ENSDARP00000125042Patched 1. (120 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
ckbaCreatine kinase, brain a; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
pax7aTranscription factor PAX7C. (507 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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