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alk alk aldh3b1 aldh3b1 mdkb mdkb aurka aurka mycn mycn mao mao aldh3a2a aldh3a2a comtb comtb th th mdka mdka ndnl2 ndnl2 lin28a lin28a h3f3a-2 h3f3a-2 dbh dbh mif mif birc5a birc5a dusp12 dusp12 lin28b lin28b aldh3a2b aldh3a2b atrx atrx cd59 cd59 ddx4 ddx4 comta comta phox2bb phox2bb ENSDARP00000132681 ENSDARP00000132681 lmo1 lmo1 ptn ptn aldh3a1 aldh3a1 aldh3b2 aldh3b2 tomt tomt bard1 bard1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
alkTyrosine-protein kinase receptor. (1181 aa)
aldh3b1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (473 aa)
mdkbMidkine-related growth factor Mdk2. (147 aa)
aurkaAurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
mycnN-myc protein; May function as a transcription factor. (503 aa)
maoAmine oxidase [flavin-containing]; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Oxidizes both 5-hydroxytryptamine (5-HT) and beta- phenylethylamine (PEA); Belongs to the flavin monoamine oxidase family. (522 aa)
aldh3a2aAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (488 aa)
comtbCatechol O-methyltransferase B; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (264 aa)
thTyrosine hydroxylase. (489 aa)
mdkaMidkine-related growth factor Mdk1. (146 aa)
ndnl2Necdin-like 2. (260 aa)
lin28aProtein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization [...] (202 aa)
h3f3a-2Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
dbhDopamine beta-hydroxylase (dopamine beta-monooxygenase). (614 aa)
mifMacrophage migration inhibitory factor. (115 aa)
birc5aBaculoviral IAP repeat-containing 5a. (190 aa)
dusp12Dual-specificity phosphatase 12. (305 aa)
lin28bLin-28 homolog B (C. elegans). (210 aa)
aldh3a2bAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (490 aa)
atrxATRX chromatin remodeler. (2013 aa)
cd59CD59 molecule (CD59 blood group). (118 aa)
ddx4DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; Belongs to the DEAD box helicase family. (716 aa)
comtaCatechol O-methyltransferase A; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Shows highest activity towards catecholestrogens and dobutamine. Also has lower activity towards L-DOPA, dopamine and epinephrine. Active towards the xenobiotic compounds methyl-DOPA, carbidopa, isoproterenol, and apomorphine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. (277 aa)
phox2bbPaired-like homeobox 2Bb. (284 aa)
ENSDARP00000132681Amine oxidase. (523 aa)
lmo1Rhombotin-1; May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. (175 aa)
ptnPleiotrophin. (158 aa)
aldh3a1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (489 aa)
aldh3b2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (502 aa)
tomtTransmembrane O-methyltransferase homolog; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function. Component of the hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity. (259 aa)
bard1BRCA1-associated RING domain 1. (687 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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