STRINGSTRING
bmpr1ab bmpr1ab mc1r mc1r bmp2a bmp2a bmp7a bmp7a lhx6 lhx6 mylz3 mylz3 tmod2 tmod2 bmp6 bmp6 pfkma pfkma f7i f7i star star smad7 smad7 lhx1b lhx1b gja8b gja8b lhx8a lhx8a nr5a1b nr5a1b smad1 smad1 ckma ckma crhb crhb cryba2a cryba2a atp2a2a atp2a2a smad3b smad3b atp2a1 atp2a1 tnnt2c tnnt2c smad3a smad3a nr3c1 nr3c1 cadm2a cadm2a cryaba cryaba pomca pomca sox9b sox9b mylpfa mylpfa ldb3a ldb3a calca calca bmp3 bmp3 pcdh1a4 pcdh1a4 crygm2b crygm2b tnnt3a tnnt3a tnnc2 tnnc2 neurod6a neurod6a pcdh1a3 pcdh1a3 ttn.2 ttn.2 mylk3 mylk3 tmod1 tmod1 smad2 smad2 bmp2b bmp2b ttn.1 ttn.1 pyya pyya crygm2a crygm2a tmod4 tmod4 cadm4 cadm4 npy1r npy1r myom1a myom1a vegfab vegfab pcdh1a pcdh1a tnnt3b tnnt3b otpa otpa neurod4 neurod4 otpb otpb avp avp cx23 cx23 pcdh17 pcdh17 pcdh1gb2 pcdh1gb2 vegfaa vegfaa igfbp3 igfbp3 pcdh2ac pcdh2ac pcdh1g18 pcdh1g18 pdlim7 pdlim7 bmpr1ba bmpr1ba nr5a2 nr5a2 tnnt1 tnnt1 ldb3b ldb3b neurod6b neurod6b cryba4 cryba4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bmpr1abReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (535 aa)
mc1rMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (323 aa)
bmp2aBone morphogenetic protein 2a. (386 aa)
bmp7aBone morphogenetic protein 7a. (432 aa)
lhx6LIM homeobox 6. (375 aa)
mylz3Fast skeletal muscle myosin light polypeptide 3. (151 aa)
tmod2Tropomodulin 2. (344 aa)
bmp6Bone morphogenetic protein 6. (417 aa)
pfkmaATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (784 aa)
f7iCoagulation factor VIIi. (443 aa)
starSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). (285 aa)
smad7Mothers against decapentaplegic homolog. (372 aa)
lhx1bLIM class homeodomain protein. (402 aa)
gja8bGap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (391 aa)
lhx8aLIM homeobox 8a. (332 aa)
nr5a1bNovel protein similar to Carassius auratus nuclear hormone receptor FTZ-F1. (502 aa)
smad1Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. (472 aa)
ckmaCreatine kinase, muscle a; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
crhbCorticotropin-releasing hormone b. (162 aa)
cryba2aCrystallin, beta A2a; Belongs to the beta/gamma-crystallin family. (197 aa)
atp2a2aCalcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (996 aa)
smad3bMothers against decapentaplegic homolog. (423 aa)
atp2a1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1005 aa)
tnnt2cTroponin T1, skeletal, slow. (290 aa)
smad3aMothers against decapentaplegic homolog. (425 aa)
nr3c1Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (746 aa)
cadm2aCell adhesion molecule 2a. (396 aa)
cryabaCrystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (168 aa)
pomcaPro-opiomelanocortin protein. (222 aa)
sox9bHMG box transcription factor Sox9b. (407 aa)
mylpfaMyosin light chain, phosphorylatable, fast skeletal muscle a. (169 aa)
ldb3aCypher/ZASP splice variant 1 gamma. (596 aa)
calcaCalcitonin/calcitonin-related polypeptide, alpha. (126 aa)
bmp3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (452 aa)
pcdh1a4Protocadherin cluster 1 alpha 4. (941 aa)
crygm2bCrystallin, gamma M2b; Belongs to the beta/gamma-crystallin family. (175 aa)
tnnt3aTroponin T type 3a (skeletal, fast). (230 aa)
tnnc2Fast skeletal muscle troponin C. (160 aa)
neurod6aNeurogenic differentiation factor 6-A; Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1. (327 aa)
pcdh1a3Protocadherin cluster 1 alpha 3. (939 aa)
ttn.2Titin, tandem duplicate 2. (26265 aa)
mylk3Myosin light chain kinase 3; Kinase that phosphorylates MYL2 in vitro (By similarity). Increases cardiomyocyte contractility (By similarity). Required for sarcomere formation in the developing heart. (716 aa)
tmod1Tropomodulin 1. (356 aa)
smad2Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. (469 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
ttn.1Titin, tandem duplicate 1. (29152 aa)
pyyaPeptide YY-A; Belongs to the NPY family. (97 aa)
crygm2aCrystallin, gamma M2a; Belongs to the beta/gamma-crystallin family. (181 aa)
tmod4Tropomodulin 4 (Muscle). (343 aa)
cadm4Cell adhesion molecule 4. (413 aa)
npy1rNeuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
myom1aMyomesin 1a (skelemin). (1483 aa)
vegfabVascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (251 aa)
pcdh1aProtocadherin 1a. (1190 aa)
tnnt3bTroponin T type 3b (skeletal, fast). (284 aa)
otpaOrthopedia homeobox a. (332 aa)
neurod4Neurogenic differentiation factor. (348 aa)
otpbHomeobox protein orthopedia B; Involved in the specification of isotocin cells. Required for the specification of dopaminergic neurons in the developing hypothalamus and posterior tuberculum; Belongs to the paired homeobox family. Bicoid subfamily. (328 aa)
avpArginine vasopressin; Belongs to the vasopressin/oxytocin family. (151 aa)
cx23Gap junction epsilon-1 protein; Has significant hemichannel activity. However, has only low- efficiency gap junction activity and probably does not function as a gap junction channel in vivo; Belongs to the connexin family. Beta-type (group I) subfamily. (207 aa)
pcdh17Protocadherin-17. (1137 aa)
pcdh1gb2Protocadherin 1 gamma b 2. (951 aa)
vegfaaVascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. (188 aa)
igfbp3Insulin-like growth factor-binding protein 3. (292 aa)
pcdh2acProtocadherin 2 alpha c. (1009 aa)
pcdh1g18Protocadherin 1 gamma 18. (257 aa)
pdlim7PDZ and LIM domain protein 7; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues (By similarity). (419 aa)
bmpr1baSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
nr5a2Nuclear receptor subfamily 5, group A, member 2. (517 aa)
tnnt1Troponin T type 1 (skeletal, slow). (342 aa)
ldb3bLIM domain-binding 3b. (292 aa)
neurod6bNeurogenic differentiation factor 6-B; Differentiation factor required for neurogenesis (By similarity). Does not act as an upstream activator of isl1. (332 aa)
cryba4Crystallin, beta A4; Belongs to the beta/gamma-crystallin family. (196 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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