STRINGSTRING
rela rela tbp tbp tnfb tnfb chuk chuk poli poli fosab fosab smad3a smad3a tcf21 tcf21 snrnp70 snrnp70 pold1 pold1 klf17 klf17 ccl38a.5 ccl38a.5 jun jun cflara cflara ctcf ctcf esr1 esr1 klf4 klf4 pola1 pola1 sp1 sp1 znf143b znf143b il6 il6 nfkb1 nfkb1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
relaV-rel avian reticuloendotheliosis viral oncogene homolog A. (455 aa)
tbpTATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity). Members of the TBP family are differentially required for transcription and development during early embryogenesis. Regulates mRNA levels in the early embryo by both transcriptional and post-transcriptional mechanisms. Required for transcription of a subs [...] (302 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
chukInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (758 aa)
poliPolymerase (DNA directed) iota. (710 aa)
fosabV-fos FBJ murine osteosarcoma viral oncogene homolog Ab. (349 aa)
smad3aMothers against decapentaplegic homolog. (425 aa)
tcf21Transcription factor 21; Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. (176 aa)
snrnp70Small nuclear ribonucleoprotein 70 (U1). (495 aa)
pold1DNA polymerase. (1105 aa)
klf17Kruppel-like factor 17. (409 aa)
ccl38a.5C-C motif chemokine. (103 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
cflaraCASP8 and FADD-like apoptosis regulator a; Belongs to the peptidase C14A family. (461 aa)
ctcfCCCTC-binding factor (zinc finger protein). (798 aa)
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (569 aa)
klf4Kruppel-like factor 4. (340 aa)
pola1DNA polymerase. (1468 aa)
sp1Sp1 transcription factor. (594 aa)
znf143bZinc finger protein 143; Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the activator element (AE) motif of the selenocysteine tRNA gene promoter (By similarity). Belongs to the GLI C2H2-type zinc-finger protein family. (647 aa)
il6Interleukin 6 (interferon, beta 2). (231 aa)
nfkb1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (540 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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