node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ccl38a.5 | il6 | ENSDARP00000061310 | ENSDARP00000131017 | C-C motif chemokine. | Interleukin 6 (interferon, beta 2). | 0.476 |
ccl38a.5 | jun | ENSDARP00000061310 | ENSDARP00000063911 | C-C motif chemokine. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.408 |
ccl38a.5 | tnfb | ENSDARP00000061310 | ENSDARP00000010728 | C-C motif chemokine. | Tumor necrosis factor b (TNF superfamily, member 2). | 0.889 |
cflara | tnfb | ENSDARP00000072840 | ENSDARP00000010728 | CASP8 and FADD-like apoptosis regulator a; Belongs to the peptidase C14A family. | Tumor necrosis factor b (TNF superfamily, member 2). | 0.585 |
chuk | jun | ENSDARP00000013115 | ENSDARP00000063911 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.529 |
chuk | nfkb1 | ENSDARP00000013115 | ENSDARP00000135800 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. | 0.939 |
chuk | rela | ENSDARP00000013115 | ENSDARP00000133181 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | V-rel avian reticuloendotheliosis viral oncogene homolog A. | 0.897 |
chuk | smad3a | ENSDARP00000013115 | ENSDARP00000045373 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Mothers against decapentaplegic homolog. | 0.563 |
chuk | tnfb | ENSDARP00000013115 | ENSDARP00000010728 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Tumor necrosis factor b (TNF superfamily, member 2). | 0.924 |
ctcf | esr1 | ENSDARP00000073595 | ENSDARP00000082277 | CCCTC-binding factor (zinc finger protein). | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.467 |
ctcf | klf4 | ENSDARP00000073595 | ENSDARP00000097662 | CCCTC-binding factor (zinc finger protein). | Kruppel-like factor 4. | 0.451 |
esr1 | ctcf | ENSDARP00000082277 | ENSDARP00000073595 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. | CCCTC-binding factor (zinc finger protein). | 0.467 |
esr1 | fosab | ENSDARP00000082277 | ENSDARP00000043297 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. | V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. | 0.876 |
esr1 | jun | ENSDARP00000082277 | ENSDARP00000063911 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.903 |
esr1 | rela | ENSDARP00000082277 | ENSDARP00000133181 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. | V-rel avian reticuloendotheliosis viral oncogene homolog A. | 0.495 |
esr1 | smad3a | ENSDARP00000082277 | ENSDARP00000045373 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. | Mothers against decapentaplegic homolog. | 0.542 |
esr1 | sp1 | ENSDARP00000082277 | ENSDARP00000110200 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. | Sp1 transcription factor. | 0.869 |
esr1 | tbp | ENSDARP00000082277 | ENSDARP00000010211 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. | TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity). Members of the TBP family are differentially required for transcription and development during early embryogenesis. Regulates mRNA levels in the early embryo by both transcriptional and post-transcriptional mechanisms. Required for transcription of a subs [...] | 0.725 |
esr1 | tnfb | ENSDARP00000082277 | ENSDARP00000010728 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. | Tumor necrosis factor b (TNF superfamily, member 2). | 0.665 |
fosab | esr1 | ENSDARP00000043297 | ENSDARP00000082277 | V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.876 |