STRINGSTRING
fyna fyna actn1 actn1 tgfb1b tgfb1b nck1b nck1b stom stom nphs2 nphs2 hcls1 hcls1 pard3ab pard3ab vcla vcla rabif rabif trpc6a trpc6a vclb vclb iqgap1 iqgap1 bcl2l11 bcl2l11 tgfb5 tgfb5 src src cd2ap cd2ap podxl podxl coq6 coq6 crb2a crb2a coq2 coq2 cybb cybb lmx1bb lmx1bb arhgdia arhgdia tgfb1a tgfb1a acta1b acta1b wt1a wt1a tgfb3 tgfb3 cfl1 cfl1 rhoab rhoab atf6 atf6 cttn cttn cfl2 cfl2 cfl1l cfl1l pdss2 pdss2 prkci prkci tjp1a tjp1a nphs1 nphs1 PARD3 PARD3 inf2 inf2 actn4 actn4 scarb2a scarb2a ptpro-2 ptpro-2 ptpro ptpro crb2b crb2b cdc42 cdc42 myh9a myh9a atg5 atg5
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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fynaTyrosine-protein kinase fyna; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in cntn1-mediated signaling (By similarity). Required for convergent extension cell movements during gastrulation, acting with yes via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling. (537 aa)
actn1Actinin, alpha 1. (902 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
nck1bCytoplasmic protein. (381 aa)
stomStomatin. (294 aa)
nphs2NPHS2 stomatin family member, podocin. (406 aa)
hcls1Hematopoietic cell-specific Lyn substrate 1. (548 aa)
pard3abPar-3 family cell polarity regulator alpha, b. (1332 aa)
vclaVinculin a. (1131 aa)
rabifRAB-interacting factor. (132 aa)
trpc6aTransient receptor potential cation channel, subfamily C, member 6a; Belongs to the transient receptor (TC 1.A.4) family. (874 aa)
vclbVinculin b. (987 aa)
iqgap1IQ motif-containing GTPase-activating protein 1. (1655 aa)
bcl2l11BCL2-like 11. (176 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
cd2apCD2-associated protein. (657 aa)
podxlPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (445 aa)
coq6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (484 aa)
crb2aCrumbs cell polarity complex component 2a. (1466 aa)
coq24-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (378 aa)
cybbCytochrome b-245, beta polypeptide (chronic granulomatous disease). (565 aa)
lmx1bbLIM homeobox transcription factor 1, beta 1. (375 aa)
arhgdiaRho GDP dissociation inhibitor (GDI) alpha. (203 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
wt1aWT1 transcription factor a. (419 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
atf6Activating transcription factor 6. (653 aa)
cttnCortactin. (536 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
cfl1lCofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. (163 aa)
pdss2Prenyl (decaprenyl) diphosphate synthase, subunit 2; Belongs to the FPP/GGPP synthase family. (370 aa)
prkciProtein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division. (588 aa)
tjp1aTight junction protein 1a; Belongs to the MAGUK family. (1689 aa)
nphs1NPHS1 adhesion molecule, nephrin. (1287 aa)
PARD3Par-3 family cell polarity regulator. (531 aa)
inf2GBD/FH3 domain-containing protein. (238 aa)
actn4Actinin, alpha 4. (923 aa)
scarb2aScavenger receptor class B, member 2a; Belongs to the CD36 family. (531 aa)
ptpro-2Protein tyrosine phosphatase receptor type O. (866 aa)
ptproProtein tyrosine phosphatase receptor type O. (385 aa)
crb2bCrumbs cell polarity complex component 2b. (1010 aa)
cdc42Cell division cycle 42. (191 aa)
myh9aMyosin, heavy chain 9a, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1964 aa)
atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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