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rrm2 rrm2 gys2 gys2 fabp1a fabp1a mcm3 mcm3 ptgs2b ptgs2b arntl1a arntl1a dusp5 dusp5 psme3 psme3 LOC100330864 LOC100330864 psma5 psma5 ptges ptges hsp90b1 hsp90b1 gclc gclc pdia4 pdia4 psmd11b psmd11b ptgs2a ptgs2a abcc2 abcc2 psmd3 psmd3 psmc3 psmc3 atf3 atf3 pdia6 pdia6 psma6b psma6b psmc4 psmc4 pfkfb3 pfkfb3 zeb1b zeb1b rbbp4 rbbp4 vtg1 vtg1 psmc6 psmc6 mcm3l mcm3l abcf2a abcf2a mcm4 mcm4 gapdh gapdh psmc1b psmc1b psma6l psma6l txn txn saa saa pcna pcna myca myca xbp1 xbp1 dnajb11 dnajb11 hspe1 hspe1 nfkbiaa nfkbiaa txnl1 txnl1 g6pca.1 g6pca.1 tp53 tp53 egln3 egln3 hamp hamp hspa5 hspa5 dusp2 dusp2 psmd7 psmd7 dusp1 dusp1 gata6 gata6 nr1h3 nr1h3 il1b il1b ccne2 ccne2 psmd1 psmd1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rrm2Ribonucleotide reductase M2 polypeptide. (386 aa)
gys2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (701 aa)
fabp1aFatty acid binding protein 1-A, liver; Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity). Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (127 aa)
mcm3DNA helicase; Belongs to the MCM family. (807 aa)
ptgs2bProstaglandin-endoperoxide synthase 2b. (606 aa)
arntl1aAryl hydrocarbon receptor nuclear translocator-like 1a. (626 aa)
dusp5Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (368 aa)
psme3Proteasome activator subunit 3. (256 aa)
LOC100330864Ribonucleoside-diphosphate reductase subunit M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (386 aa)
psma5Proteasome subunit alpha type. (241 aa)
ptgesMicrosomal prostaglandin E synthase 1. (146 aa)
hsp90b1Heat shock protein 90, beta (Grp94), member 1. (793 aa)
gclcGlutamate-cysteine ligase, catalytic subunit. (631 aa)
pdia4Protein disulfide-isomerase A4; Belongs to the protein disulfide isomerase family. (642 aa)
psmd11b26S proteasome non-ATPase regulatory subunit 11B; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmd11b is required for proteasome assembly (By similarity). (422 aa)
ptgs2aProstaglandin-endoperoxide synthase 2a. (601 aa)
abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 2. (1553 aa)
psmd3Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (503 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (404 aa)
atf3Activating transcription factor 3. (202 aa)
pdia6Protein disulfide isomerase family A, member 6; Belongs to the protein disulfide isomerase family. (440 aa)
psma6bProteasome subunit alpha type. (246 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
pfkfb36-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3. (536 aa)
zeb1bZinc finger E-box-binding homeobox 1b. (1078 aa)
rbbp4Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. (424 aa)
vtg1Vitellogenin 1. (1362 aa)
psmc6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (389 aa)
mcm3lDNA helicase; Belongs to the MCM family. (807 aa)
abcf2aATP-binding cassette, sub-family F (GCN20), member 2a. (613 aa)
mcm4DNA helicase; Belongs to the MCM family. (845 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
psmc1bProteasome (Prosome, macropain) 26S subunit, ATPase, 1b; Belongs to the AAA ATPase family. (440 aa)
psma6lProteasome subunit alpha type. (252 aa)
txnThioredoxin; Belongs to the thioredoxin family. (107 aa)
saaSerum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (121 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
xbp1Transcription factor Treb5. (263 aa)
dnajb11DnaJ heat shock protein family (Hsp40) member B11. (360 aa)
hspe1Heat shock 10 protein 1 (Chaperonin 10); Belongs to the GroES chaperonin family. (100 aa)
nfkbiaaNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (310 aa)
txnl1Thioredoxin-like 1. (289 aa)
g6pca.1Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (352 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
egln3Egl-9 family hypoxia-inducible factor 3. (243 aa)
hampHepcidin-2; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family. (91 aa)
hspa5Immunoglobulin binding protein; Belongs to the heat shock protein 70 family. (650 aa)
dusp2Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (333 aa)
psmd7Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog). (327 aa)
dusp1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (369 aa)
gata6GATA-binding protein 6. (501 aa)
nr1h3Nuclear receptor subfamily 1, group H, member 3. (441 aa)
il1bInterleukin-1. (284 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (392 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (993 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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