STRINGSTRING
flna flna zyx zyx map4l map4l pfn1 pfn1 csnk1a1 csnk1a1 vcla vcla vclb vclb myca myca iqgap1 iqgap1 fscn2b fscn2b pfn2 pfn2 fscn1b fscn1b fscn1a fscn1a vaspb vaspb fscn2a fscn2a scinlb scinlb acta1b acta1b pfn2l pfn2l gsnb gsnb scin scin flnca flnca twist1a twist1a ptk2ab ptk2ab spast spast gsna gsna flncb flncb cfl1 cfl1 rhoab rhoab rho rho cfl2 cfl2 cfl1l cfl1l cdh2 cdh2 actn3b actn3b scinla scinla ctnnb1 ctnnb1 Flnb Flnb fign fign tln2b tln2b cdh1 cdh1 axin1 axin1 tln2a tln2a tln1 tln1 cdc42 cdc42 X1WCU6_DANRE X1WCU6_DANRE flnb flnb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
flnaFilamin A, alpha (actin-binding protein 280). (2553 aa)
zyxZyxin. (608 aa)
map4lMicrotubule-associated protein. (1067 aa)
pfn1Profilin; Belongs to the profilin family. (141 aa)
csnk1a1Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily. (365 aa)
vclaVinculin a. (1131 aa)
vclbVinculin b. (987 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
iqgap1IQ motif-containing GTPase-activating protein 1. (1655 aa)
fscn2bFascin. (490 aa)
pfn2Profilin; Belongs to the profilin family. (140 aa)
fscn1bFascin. (494 aa)
fscn1aFascin. (491 aa)
vaspbVasodilator-stimulated phosphoprotein b. (445 aa)
fscn2aFascin. (488 aa)
scinlbScinderin-like b. (720 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
pfn2lProfilin; Belongs to the profilin family. (139 aa)
gsnbGelsolin b. (728 aa)
scinScinderin. (733 aa)
flncaFilamin C, gamma a (actin-binding protein 280). (2719 aa)
twist1aTwist family bHLH transcription factor 1a. (171 aa)
ptk2abProtein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1050 aa)
spastSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (570 aa)
gsnaGelsolin a. (729 aa)
flncbFilamin C, gamma b (actin-binding protein 280). (2773 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
rhoRhodopsin; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). (354 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
cfl1lCofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. (163 aa)
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
actn3bActinin alpha 3b. (898 aa)
scinlaScinderin-like a. (720 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
FlnbUncharacterized protein. (157 aa)
fignFidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, suppressing microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome (By similarity); [...] (747 aa)
tln2bTalin 2b. (1537 aa)
cdh1Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa)
axin1Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (835 aa)
tln2aTalin 2a. (2543 aa)
tln1Talin 1. (2544 aa)
cdc42Cell division cycle 42. (191 aa)
X1WCU6_DANREProfilin; Belongs to the profilin family. (127 aa)
flnbFilamin B, beta (actin-binding protein 278). (2233 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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