(9 nodes) (2014) Use of antagonists and morpholinos in loss-of-function analyses: estrogen receptor ESR2a mediates the effects of 17alpha-ethinylestradiol on primordial germ cell distribution in zebrafish. network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Edges represent protein-protein associations

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Your Input:
	tbx16	T-box transcription factor 16. (470 aa)
	cxcl12a	Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
	cxcr4b	Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	ackr3b	Atypical chemokine receptor 3b; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (569 aa)
	nanos3	Nanos homolog 3; Belongs to the nanos family. (159 aa)
	esr2a	Estrogen receptor beta2. (553 aa)
	esr2b	Estrogen receptor 2b. (592 aa)
	nanos1	Nanos homolog 1; Acts as a translational repressor. Can mediate repression affecting different steps in the translation process: cap-driven, IRES- driven, polyadenylated RNAs or nonpolyadenylated RNAs (By similarity). Essential for the development of primordial germ cells (PGCs) by ensuring their proper migration and survival. (228 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ackr3b	cxcl12a	ENSDARP00000063664	ENSDARP00000053945	Atypical chemokine receptor 3b; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family.	0.999
ackr3b	cxcr4b	ENSDARP00000063664	ENSDARP00000061498	Atypical chemokine receptor 3b; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family.	0.686
cxcl12a	ackr3b	ENSDARP00000053945	ENSDARP00000063664	Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family.	Atypical chemokine receptor 3b; Belongs to the G-protein coupled receptor 1 family.	0.999
cxcl12a	cxcr4b	ENSDARP00000053945	ENSDARP00000061498	Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family.	Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family.	0.999
cxcl12a	nanos3	ENSDARP00000053945	ENSDARP00000089386	Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family.	Nanos homolog 3; Belongs to the nanos family.	0.545
cxcr4b	ackr3b	ENSDARP00000061498	ENSDARP00000063664	Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family.	Atypical chemokine receptor 3b; Belongs to the G-protein coupled receptor 1 family.	0.686
cxcr4b	cxcl12a	ENSDARP00000061498	ENSDARP00000053945	Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family.	0.999
cxcr4b	esr1	ENSDARP00000061498	ENSDARP00000082277	Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.448
cxcr4b	nanos3	ENSDARP00000061498	ENSDARP00000089386	Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family.	Nanos homolog 3; Belongs to the nanos family.	0.410
esr1	cxcr4b	ENSDARP00000082277	ENSDARP00000061498	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family.	0.448
esr1	esr2b	ENSDARP00000082277	ENSDARP00000118673	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Estrogen receptor 2b.	0.922
esr2b	esr1	ENSDARP00000118673	ENSDARP00000082277	Estrogen receptor 2b.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.922
nanos3	cxcl12a	ENSDARP00000089386	ENSDARP00000053945	Nanos homolog 3; Belongs to the nanos family.	Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family.	0.545
nanos3	cxcr4b	ENSDARP00000089386	ENSDARP00000061498	Nanos homolog 3; Belongs to the nanos family.	Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family.	0.410

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