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otogl otogl slc9a3r1a slc9a3r1a smurf1 smurf1 cfl1l cfl1l cfl2 cfl2 ckmt1 ckmt1 msna msna myo3b myo3b adgrv1 adgrv1 cfl1 cfl1 ckbb ckbb gpsm2 gpsm2 cdh23 cdh23 gsna gsna vangl1 vangl1 clic5b clic5b vangl2 vangl2 ift88 ift88 ckma ckma epb41b epb41b scin scin gsnb gsnb gnai3 gnai3 smurf2 smurf2 ckmt2b ckmt2b acta1b acta1b ckmb ckmb ENSDARP00000060652 ENSDARP00000060652 twf2 twf2 tectb tectb scrib scrib ezrb ezrb scinlb scinlb tecta tecta fscn2a fscn2a kcnq1.1 kcnq1.1 ush2a ush2a fzd3a fzd3a TMC1 TMC1 ptk7a ptk7a LOC556989 LOC556989 ckmt2a ckmt2a sec24b sec24b fscn2b fscn2b alms1 alms1 whrna whrna vezt vezt bbs1 bbs1 kif3a kif3a fzd3b fzd3b LOC101887046 LOC101887046 dchs1b dchs1b myo3a myo3a elmod3 elmod3 calb1 calb1 elmod1 elmod1 atp8b1 atp8b1 whrnb whrnb loxhd1a loxhd1a pvalb7 pvalb7 espn espn tbc1d24 tbc1d24 eps8l2 eps8l2 triobpb triobpb atp2b2 atp2b2 cib2 cib2 pcdh15a pcdh15a ckba ckba eps8a eps8a scinla scinla pdzd7a pdzd7a ttc8 ttc8 fzd6 fzd6 clrn1 clrn1 pcdh15b pcdh15b LOC100004499 LOC100004499 otog otog myo7aa myo7aa fat4 fat4 LOC101882228 LOC101882228 ush1gb ush1gb tjp1a tjp1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
otoglOtogelin-like. (2489 aa)
slc9a3r1aNa(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (384 aa)
smurf1E3 ubiquitin-protein ligase. (731 aa)
cfl1lCofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. (163 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
ckmt1Creatine kinase, mitochondrial 1; Belongs to the ATP:guanido phosphotransferase family. (417 aa)
msnaMoesin a. (579 aa)
myo3bMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1272 aa)
adgrv1Adhesion G-protein coupled receptor V1; Receptor that may have an important role in the development of the sensory nervous system. (6198 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
ckbbBrain-subtype creatine kinase; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
gpsm2G protein-signaling modulator 2. (649 aa)
cdh23Cadherin-related 23. (2883 aa)
gsnaGelsolin a. (729 aa)
vangl1Vang-like protein. (527 aa)
clic5bChloride intracellular channel protein; Belongs to the chloride channel CLIC family. (408 aa)
vangl2Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa)
ift88Intraflagellar transport 88 homolog. (824 aa)
ckmaCreatine kinase, muscle a; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
epb41bErythrocyte membrane protein band 4.1 (Elliptocytosis 1, RH-linked). (1534 aa)
scinScinderin. (733 aa)
gsnbGelsolin b. (728 aa)
gnai3Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 3. (354 aa)
smurf2E3 ubiquitin-protein ligase SMURF2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (765 aa)
ckmt2bCreatine kinase, mitochondrial 2b (sarcomeric); Belongs to the ATP:guanido phosphotransferase family. (413 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
ckmbCreatine kinase, muscle b; Belongs to the ATP:guanido phosphotransferase family. (380 aa)
ENSDARP00000060652Si:ch211-57i17.5. (199 aa)
twf2Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin (By similarity). (347 aa)
tectbZgc:101843 protein. (336 aa)
scribProtein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Regulates the caudal migration of the nVII motor neurons. Required for convergent extension movements during gastrulation. (1724 aa)
ezrbEzrin b. (583 aa)
scinlbScinderin-like b. (720 aa)
tectaTectorin alpha. (2201 aa)
fscn2aFascin. (488 aa)
kcnq1.1Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (655 aa)
ush2aUsher syndrome 2A (autosomal recessive, mild). (5236 aa)
fzd3aTransmembrane receptor frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (685 aa)
TMC1Transmembrane channel-like protein 1; Probable ion channel required for the normal function of hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery ; Belongs to the TMC family. (990 aa)
ptk7aProtein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1061 aa)
LOC556989Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1124 aa)
ckmt2aCreatine kinase, mitochondrial 2a (sarcomeric); Belongs to the ATP:guanido phosphotransferase family. (417 aa)
sec24bSEC24 homolog B, COPII coat complex component. (1184 aa)
fscn2bFascin. (490 aa)
alms1ALMS1 centrosome and basal body-associated protein. (2105 aa)
whrnaWhirlin a. (939 aa)
veztVezatin, adherens junctions transmembrane protein. (783 aa)
bbs1Bardet-Biedl syndrome 1. (588 aa)
kif3aKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (701 aa)
fzd3bFrizzled class receptor 3b; Belongs to the G-protein coupled receptor Fz/Smo family. (667 aa)
LOC101887046Potassium voltage-gated channel, KQT-like subfamily, member 4. (173 aa)
dchs1bDachsous cadherin-related 1b. (3298 aa)
myo3aMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1775 aa)
elmod3ELMO/CED-12 domain-containing 3. (327 aa)
calb1Calbindin 1. (260 aa)
elmod1ELMO/CED-12 domain-containing 1. (327 aa)
atp8b1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1249 aa)
whrnbWhirlin b. (946 aa)
loxhd1aLipoxygenase homology domains 1a. (2122 aa)
pvalb7Parvalbumin-7; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). (109 aa)
espnEspin. (873 aa)
tbc1d24TBC1 domain family, member 24. (606 aa)
eps8l2EPS8-like 2. (670 aa)
triobpbTRIO and F-actin-binding protein b. (532 aa)
atp2b2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1253 aa)
cib2Calcium and integrin-binding family member 2. (187 aa)
pcdh15aProtocadherin-related 15a. (1796 aa)
ckbaCreatine kinase, brain a; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
eps8aEpidermal growth factor receptor pathway substrate 8a. (804 aa)
scinlaScinderin-like a. (720 aa)
pdzd7aPDZ domain-containing 7a. (954 aa)
ttc8Tetratricopeptide repeat domain 8. (268 aa)
fzd6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (617 aa)
clrn1Clrn1 protein. (232 aa)
pcdh15bProtocadherin-related 15b. (1907 aa)
LOC100004499Stereocilin. (1934 aa)
otogOtogelin. (3120 aa)
myo7aaMyosin VIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2190 aa)
fat4FAT atypical cadherin 4. (4531 aa)
LOC101882228FH2 domain-containing protein. (287 aa)
ush1gbUsher syndrome 1Gb (autosomal recessive). (488 aa)
tjp1aTight junction protein 1a; Belongs to the MAGUK family. (1689 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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