(18 nodes) (2014) New paradigms in the establishment and maintenance of gradients during directed cell migration. network (Danio rerio)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	ccr2-2	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	csf3a	Colony-stimulating factor 3 (granulocyte) a. (224 aa)
	ntn1a	Netrin-1a. (603 aa)
	csf3b	Colony-stimulating factor 3 (granulocyte) b. (217 aa)
	ntn2	Netrin 2. (609 aa)
	ccl25b	Chemokine (C-C motif) ligand 25b. (106 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	slc9a1b	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (653 aa)
	fgf8a	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
	ntn1b	Netrin 1b. (602 aa)
	cxcl12a	Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
	ccl38a.5	C-C motif chemokine. (103 aa)
	cxcr4b	Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	mmp9	Matrix metallopeptidase 9. (680 aa)
	ackr3b	Atypical chemokine receptor 3b; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	duox	Dual oxidase. (1519 aa)
	egf	Epidermal growth factor. (1114 aa)
	ccr2	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (354 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ackr3b	ccl25b	ENSDARP00000063664	ENSDARP00000095178	Atypical chemokine receptor 3b; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-C motif) ligand 25b.	0.452
ackr3b	cxcl12a	ENSDARP00000063664	ENSDARP00000053945	Atypical chemokine receptor 3b; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family.	0.999
ackr3b	cxcr4b	ENSDARP00000063664	ENSDARP00000061498	Atypical chemokine receptor 3b; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family.	0.686
ccl25b	ackr3b	ENSDARP00000095178	ENSDARP00000063664	Chemokine (C-C motif) ligand 25b.	Atypical chemokine receptor 3b; Belongs to the G-protein coupled receptor 1 family.	0.452
ccl25b	ccr2-2	ENSDARP00000095178	ENSDARP00000142057	Chemokine (C-C motif) ligand 25b.	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.615
ccl25b	cxcl12a	ENSDARP00000095178	ENSDARP00000053945	Chemokine (C-C motif) ligand 25b.	Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family.	0.841
ccl25b	cxcr4b	ENSDARP00000095178	ENSDARP00000061498	Chemokine (C-C motif) ligand 25b.	Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family.	0.400
ccl38a.5	ccr2	ENSDARP00000061310	ENSDARP00000142081	C-C motif chemokine.	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.999
ccl38a.5	ccr2-2	ENSDARP00000061310	ENSDARP00000142057	C-C motif chemokine.	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.999
ccl38a.5	cxcl12a	ENSDARP00000061310	ENSDARP00000053945	C-C motif chemokine.	Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family.	0.867
ccl38a.5	cxcr4b	ENSDARP00000061310	ENSDARP00000061498	C-C motif chemokine.	Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family.	0.765
ccl38a.5	egf	ENSDARP00000061310	ENSDARP00000069126	C-C motif chemokine.	Epidermal growth factor.	0.515
ccl38a.5	mmp9	ENSDARP00000061310	ENSDARP00000062844	C-C motif chemokine.	Matrix metallopeptidase 9.	0.742
ccr2	ccl38a.5	ENSDARP00000142081	ENSDARP00000061310	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.999
ccr2	ccr2-2	ENSDARP00000142081	ENSDARP00000142057	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.900
ccr2	cxcl12a	ENSDARP00000142081	ENSDARP00000053945	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family.	0.813
ccr2	mmp9	ENSDARP00000142081	ENSDARP00000062844	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	Matrix metallopeptidase 9.	0.646
ccr2-2	ccl25b	ENSDARP00000142057	ENSDARP00000095178	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-C motif) ligand 25b.	0.615
ccr2-2	ccl38a.5	ENSDARP00000142057	ENSDARP00000061310	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.999
ccr2-2	ccr2	ENSDARP00000142057	ENSDARP00000142081	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.900

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