STRINGSTRING
insb insb echs1 echs1 foxa2 foxa2 fgfr3 fgfr3 fgfr1a fgfr1a cp cp C20H6orf58 C20H6orf58 fabp2 fabp2 epas1a epas1a wnt2bb wnt2bb ins ins bms1 bms1 hdac3 hdac3 fabp10a fabp10a cxcr4b cxcr4b rbm19 rbm19 C20H20H6orf58 C20H20H6orf58 gdf11 gdf11 zgc:173552 zgc:173552 igfbp2a igfbp2a epas1b epas1b zgc:113983 zgc:113983 pou3f2b pou3f2b hmgcra hmgcra h3f3a-2 h3f3a-2 epoa epoa birc5a birc5a fasn fasn grna grna tp53 tp53 birc5b birc5b zgc:162611-2 zgc:162611-2 e2f4 e2f4 hif1al hif1al hmgcrb hmgcrb uhrf1 uhrf1 gata4 gata4 sox17 sox17 igfbp1a igfbp1a hhex hhex hmgcs1 hmgcs1 foxa1 foxa1 hist2h3ca1 hist2h3ca1 fgfr4 fgfr4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
echs1Enoyl CoA hydratase, short chain, 1, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (291 aa)
foxa2Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. (409 aa)
fgfr3Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] (819 aa)
fgfr1aFibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa)
cpCeruloplasmin; Belongs to the multicopper oxidase family. (1087 aa)
C20H6orf58Protein leg1b; Involved in early development of liver, exocrine pancreas and intestine, probably through cell cycle regulation. In liver, its function is partially redundant with leg1a function. (364 aa)
fabp2Fatty acid-binding protein 2, intestinal; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
epas1aEndothelial PAS domain protein 1a. (842 aa)
wnt2bbProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
bms1BMS1 ribosome biogenesis factor. (1221 aa)
hdac3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May play a role in the regulation of the circadian clock in a deacetylase activity-independent manner (By similarity). (428 aa)
fabp10aFatty acid-binding protein 10-A, liver basic; Binds hydrophobic ligands, such as cholate, in the cytoplasm. May be involved in intracellular lipid transport (By similarity). Binds one cholate per subunit. (126 aa)
cxcr4bChemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. (353 aa)
rbm19RNA-binding motif protein 19. (927 aa)
C20H20H6orf58Protein leg1a; Important for early development of liver, exocrine pancreas and intestine, probably through cell cycle regulation. In liver, its function is partially redundant with leg1b function. (364 aa)
gdf11Growth differentiation factor 11. (390 aa)
zgc:173552Histone H3; Belongs to the histone H3 family. (136 aa)
igfbp2aInsulin-like growth factor-binding protein 2-A; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (276 aa)
epas1bEndothelial PAS domain protein 1b. (834 aa)
zgc:113983Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
pou3f2bPOU domain, class 3, transcription factor 2; Transcription factor that may play important roles in patterning the embryonic brain; Belongs to the POU transcription factor family. Class-3 subfamily. (378 aa)
hmgcra3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa)
h3f3a-2Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
epoaErythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Belongs to the EPO/TPO family. (183 aa)
birc5aBaculoviral IAP repeat-containing 5a. (190 aa)
fasnCoiled-coil domain containing 57. (2511 aa)
grnaGranulin a. (1049 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
birc5bBaculoviral IAP repeat-containing 5b. (144 aa)
zgc:162611-2Si:dkey-108k21.24. (151 aa)
e2f4E2F transcription factor 4. (404 aa)
hif1alHypoxia-inducible factor 1 subunit alpha,-like. (626 aa)
hmgcrb3-hydroxy-3-methylglutaryl coenzyme A reductase. (844 aa)
uhrf1E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...] (775 aa)
gata4GATA-binding protein 4. (352 aa)
sox17SRY-box transcription factor 17. (413 aa)
igfbp1aInsulin-like growth factor-binding protein 1a. (262 aa)
hhexHematopoietically-expressed homeobox protein hhex; Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells. Plays a role in embryonic dorsoventral patterning by regulating bmp expression. May establish anterior identity. Functions in the embryo to regulate liver development. Functions extraembryonically to generate organ chirality. (177 aa)
hmgcs13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (519 aa)
foxa1Forkhead box A1. (427 aa)
hist2h3ca1Histone H3; Belongs to the histone H3 family. (136 aa)
fgfr4Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] (923 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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