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eya3 eya3 eya1 eya1 myf5 myf5 wnt4 wnt4 tnnc2 tnnc2 six3b six3b six1a six1a atp2a1 atp2a1 pax3a pax3a six1b six1b myog myog myod1 myod1 sox6 sox6 msx1a msx1a plaat1 plaat1 ctnnb1 ctnnb1 hdac4 hdac4 pax7a pax7a met met
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
eya3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (617 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (609 aa)
myf5Myogenic factor. (237 aa)
wnt4Protein Wnt-4a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development. (352 aa)
tnnc2Fast skeletal muscle troponin C. (160 aa)
six3bSine oculis homeobox homolog 3b. (293 aa)
six1aHomeobox protein six1a; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells (By similarity). Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles; Belongs to the SIX/Sine oculis homeobox family. (283 aa)
atp2a1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1005 aa)
pax3aTranscription factor PAX3. (509 aa)
six1bHomeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa)
myogMyogenin. (256 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
sox6SRY-box transcription factor 6. (816 aa)
msx1aMuscle segment homeobox 1a. (233 aa)
plaat1Phospholipase A and acyltransferase 1. (179 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa)
pax7aTranscription factor PAX7C. (507 aa)
metMET proto-oncogene, receptor tyrosine kinase. (1382 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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