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ccnd1 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa) | ||||
notch1a | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa) | ||||
cdh1 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa) | ||||
pax6a | Paired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. (451 aa) | ||||
sufu | Suppressor of fused homolog. (485 aa) | ||||
talpid3 | Protein TALPID3; Required for ciliogenesis and sonic hedgehog/SHH signaling. Belongs to the TALPID3 family. (1548 aa) | ||||
ptch2 | Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa) | ||||
tgfb2 | Transforming growth factor, beta 2. (413 aa) | ||||
cdk1 | Cell division control protein 2; Belongs to the protein kinase superfamily. (302 aa) | ||||
mafa | V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a); Belongs to the bZIP family. (325 aa) | ||||
cdon | Cell adhesion molecule-related/down-regulated by oncogenes. (1125 aa) | ||||
hhip | Hedgehog-interacting protein. (693 aa) | ||||
ihhb | Indian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa) | ||||
ihha | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa) | ||||
ENSDARP00000125042 | Patched 1. (120 aa) | ||||
pax2a | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa) | ||||
cryaa | Crystallin, alpha A; Belongs to the small heat shock protein (HSP20) family. (173 aa) | ||||
ccnb1 | Cyclin B1; Belongs to the cyclin family. (397 aa) | ||||
cdkn1ca | Cyclin-dependent kinase inhibitor 1C (P57, Kip2). (212 aa) | ||||
gli3 | GLI family zinc finger 3. (1553 aa) | ||||
shhb | Tiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa) | ||||
smox | Spermine oxidase. (539 aa) | ||||
notch1b | Notch receptor 1b. (2465 aa) | ||||
kif7 | Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. (1363 aa) | ||||
rbpja | Recombination signal-binding protein for immunoglobulin kappa J region a. (496 aa) | ||||
ptch1 | Protein patched homolog 1. (1475 aa) | ||||
smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) | ||||
gli2a | GLI family zinc finger 2a. (1439 aa) | ||||
cdc25b | Cell division cycle 25B. (563 aa) |