STRINGSTRING
ccnd1 ccnd1 notch1a notch1a cdh1 cdh1 pax6a pax6a sufu sufu talpid3 talpid3 ptch2 ptch2 tgfb2 tgfb2 cdk1 cdk1 mafa mafa cdon cdon hhip hhip ihhb ihhb ihha ihha ENSDARP00000125042 ENSDARP00000125042 pax2a pax2a cryaa cryaa ccnb1 ccnb1 cdkn1ca cdkn1ca gli3 gli3 shhb shhb smox smox notch1b notch1b kif7 kif7 rbpja rbpja ptch1 ptch1 smo smo gli2a gli2a cdc25b cdc25b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ccnd1G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
cdh1Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa)
pax6aPaired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. (451 aa)
sufuSuppressor of fused homolog. (485 aa)
talpid3Protein TALPID3; Required for ciliogenesis and sonic hedgehog/SHH signaling. Belongs to the TALPID3 family. (1548 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
tgfb2Transforming growth factor, beta 2. (413 aa)
cdk1Cell division control protein 2; Belongs to the protein kinase superfamily. (302 aa)
mafaV-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a); Belongs to the bZIP family. (325 aa)
cdonCell adhesion molecule-related/down-regulated by oncogenes. (1125 aa)
hhipHedgehog-interacting protein. (693 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
ihhaHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
ENSDARP00000125042Patched 1. (120 aa)
pax2aPaired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa)
cryaaCrystallin, alpha A; Belongs to the small heat shock protein (HSP20) family. (173 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (397 aa)
cdkn1caCyclin-dependent kinase inhibitor 1C (P57, Kip2). (212 aa)
gli3GLI family zinc finger 3. (1553 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
smoxSpermine oxidase. (539 aa)
notch1bNotch receptor 1b. (2465 aa)
kif7Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. (1363 aa)
rbpjaRecombination signal-binding protein for immunoglobulin kappa J region a. (496 aa)
ptch1Protein patched homolog 1. (1475 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
cdc25bCell division cycle 25B. (563 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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