(13 nodes) (2015) BRF1 mutations alter RNA polymerase III-dependent transcription and cause neurodevelopmental anomalies. network (Danio rerio)

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Your Input:
	polr3b	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1130 aa)
	mafb	Transcription factor Maf; Acts as a transcriptional activator or repressor. Belongs to the bZIP family. Maf subfamily. (327 aa)
	polr3a	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1390 aa)
	brf2	Transcription factor IIIB 50 kDa subunit; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress; Belongs to the TFIIB family. (423 aa)
	rdh12	Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (320 aa)
	grna	Granulin a. (1049 aa)
	mafa	V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a); Belongs to the bZIP family. (325 aa)
	pola1	DNA polymerase. (1468 aa)
	tbp	TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity). Members of the TBP family are differentially required for transcription and development during early embryogenesis. Regulates mRNA levels in the early embryo by both transcriptional and post-transcriptional mechanisms. Required for transcription of a subs [...] (302 aa)
	brf1a	BRF1 RNA polymerase III transcription initiation factor subunit a. (661 aa)
	brf1b	BRF1 RNA polymerase III transcription initiation factor subunit b. (693 aa)
	poli	Polymerase (DNA directed) iota. (710 aa)
	pold1	DNA polymerase. (1105 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
brf1a	brf1b	ENSDARP00000029653	ENSDARP00000038308	BRF1 RNA polymerase III transcription initiation factor subunit a.	BRF1 RNA polymerase III transcription initiation factor subunit b.	0.562
brf1a	brf2	ENSDARP00000029653	ENSDARP00000130569	BRF1 RNA polymerase III transcription initiation factor subunit a.	Transcription factor IIIB 50 kDa subunit; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress; Belongs to the TFIIB family.	0.933
brf1a	polr3a	ENSDARP00000029653	ENSDARP00000139214	BRF1 RNA polymerase III transcription initiation factor subunit a.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.932
brf1a	polr3b	ENSDARP00000029653	ENSDARP00000085899	BRF1 RNA polymerase III transcription initiation factor subunit a.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.932
brf1a	tbp	ENSDARP00000029653	ENSDARP00000010211	BRF1 RNA polymerase III transcription initiation factor subunit a.	TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity). Members of the TBP family are differentially required for transcription and development during early embryogenesis. Regulates mRNA levels in the early embryo by both transcriptional and post-transcriptional mechanisms. Required for transcription of a subs [...]	0.972
brf1b	brf1a	ENSDARP00000038308	ENSDARP00000029653	BRF1 RNA polymerase III transcription initiation factor subunit b.	BRF1 RNA polymerase III transcription initiation factor subunit a.	0.562
brf1b	brf2	ENSDARP00000038308	ENSDARP00000130569	BRF1 RNA polymerase III transcription initiation factor subunit b.	Transcription factor IIIB 50 kDa subunit; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress; Belongs to the TFIIB family.	0.675
brf1b	polr3a	ENSDARP00000038308	ENSDARP00000139214	BRF1 RNA polymerase III transcription initiation factor subunit b.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.948
brf1b	polr3b	ENSDARP00000038308	ENSDARP00000085899	BRF1 RNA polymerase III transcription initiation factor subunit b.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.949
brf1b	tbp	ENSDARP00000038308	ENSDARP00000010211	BRF1 RNA polymerase III transcription initiation factor subunit b.	TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity). Members of the TBP family are differentially required for transcription and development during early embryogenesis. Regulates mRNA levels in the early embryo by both transcriptional and post-transcriptional mechanisms. Required for transcription of a subs [...]	0.896
brf2	brf1a	ENSDARP00000130569	ENSDARP00000029653	Transcription factor IIIB 50 kDa subunit; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress; Belongs to the TFIIB family.	BRF1 RNA polymerase III transcription initiation factor subunit a.	0.933
brf2	brf1b	ENSDARP00000130569	ENSDARP00000038308	Transcription factor IIIB 50 kDa subunit; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress; Belongs to the TFIIB family.	BRF1 RNA polymerase III transcription initiation factor subunit b.	0.675
brf2	polr3a	ENSDARP00000130569	ENSDARP00000139214	Transcription factor IIIB 50 kDa subunit; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress; Belongs to the TFIIB family.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.914
brf2	polr3b	ENSDARP00000130569	ENSDARP00000085899	Transcription factor IIIB 50 kDa subunit; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress; Belongs to the TFIIB family.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.926
brf2	rdh12	ENSDARP00000130569	ENSDARP00000121735	Transcription factor IIIB 50 kDa subunit; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress; Belongs to the TFIIB family.	Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.406
brf2	tbp	ENSDARP00000130569	ENSDARP00000010211	Transcription factor IIIB 50 kDa subunit; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress; Belongs to the TFIIB family.	TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity). Members of the TBP family are differentially required for transcription and development during early embryogenesis. Regulates mRNA levels in the early embryo by both transcriptional and post-transcriptional mechanisms. Required for transcription of a subs [...]	0.964
pola1	pold1	ENSDARP00000106559	ENSDARP00000055858	DNA polymerase.	DNA polymerase.	0.953
pola1	poli	ENSDARP00000106559	ENSDARP00000041370	DNA polymerase.	Polymerase (DNA directed) iota.	0.600
pold1	pola1	ENSDARP00000055858	ENSDARP00000106559	DNA polymerase.	DNA polymerase.	0.953
pold1	poli	ENSDARP00000055858	ENSDARP00000041370	DNA polymerase.	Polymerase (DNA directed) iota.	0.721

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