node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ccbe1 | fli1a | ENSDARP00000106577 | ENSDARP00000071331 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | Fli-1 proto-oncogene, ETS transcription factor a. | 0.569 |
ccbe1 | itga9 | ENSDARP00000106577 | ENSDARP00000045474 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | Integrin, alpha 9; Belongs to the integrin alpha chain family. | 0.700 |
ccbe1 | kdrl | ENSDARP00000106577 | ENSDARP00000134625 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | Vascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | 0.561 |
ccbe1 | lyve1b | ENSDARP00000106577 | ENSDARP00000155383 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | Lymphatic vessel endothelial hyaluronic receptor 1b. | 0.833 |
ccbe1 | vegfc | ENSDARP00000106577 | ENSDARP00000092263 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.960 |
cxcl12a | cxcr4b | ENSDARP00000053945 | ENSDARP00000061498 | Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. | Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. | 0.999 |
cxcl12a | kdrl | ENSDARP00000053945 | ENSDARP00000134625 | Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. | Vascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | 0.748 |
cxcl12a | lyve1b | ENSDARP00000053945 | ENSDARP00000155383 | Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. | Lymphatic vessel endothelial hyaluronic receptor 1b. | 0.593 |
cxcl12a | tp53 | ENSDARP00000053945 | ENSDARP00000116736 | Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.565 |
cxcl12a | vcam1b | ENSDARP00000053945 | ENSDARP00000144690 | Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. | Vascular cell adhesion molecule 1b. | 0.840 |
cxcl12a | vegfc | ENSDARP00000053945 | ENSDARP00000092263 | Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.684 |
cxcr4b | cxcl12a | ENSDARP00000061498 | ENSDARP00000053945 | Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. | Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. | 0.999 |
cxcr4b | kdrl | ENSDARP00000061498 | ENSDARP00000134625 | Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. | Vascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | 0.744 |
cxcr4b | lyve1b | ENSDARP00000061498 | ENSDARP00000155383 | Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. | Lymphatic vessel endothelial hyaluronic receptor 1b. | 0.505 |
cxcr4b | tp53 | ENSDARP00000061498 | ENSDARP00000116736 | Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.617 |
cxcr4b | vcam1b | ENSDARP00000061498 | ENSDARP00000144690 | Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. | Vascular cell adhesion molecule 1b. | 0.814 |
cxcr4b | vegfc | ENSDARP00000061498 | ENSDARP00000092263 | Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.627 |
fli1a | ccbe1 | ENSDARP00000071331 | ENSDARP00000106577 | Fli-1 proto-oncogene, ETS transcription factor a. | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | 0.569 |
fli1a | kdrl | ENSDARP00000071331 | ENSDARP00000134625 | Fli-1 proto-oncogene, ETS transcription factor a. | Vascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | 0.979 |
fli1a | lyve1b | ENSDARP00000071331 | ENSDARP00000155383 | Fli-1 proto-oncogene, ETS transcription factor a. | Lymphatic vessel endothelial hyaluronic receptor 1b. | 0.693 |