node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acta1b | ccn2a | ENSDARP00000058628 | ENSDARP00000063027 | Actin alpha 1, skeletal muscle b. | Novel protein similar to vertebrate connective tissue growth factor (CTGF). | 0.654 |
acta1b | cd44a | ENSDARP00000058628 | ENSDARP00000110970 | Actin alpha 1, skeletal muscle b. | CD44 molecule (Indian blood group) a. | 0.814 |
acta1b | cdh1 | ENSDARP00000058628 | ENSDARP00000136579 | Actin alpha 1, skeletal muscle b. | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | 0.968 |
acta1b | ctnnb1 | ENSDARP00000058628 | ENSDARP00000139205 | Actin alpha 1, skeletal muscle b. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.967 |
acta1b | kdrl | ENSDARP00000058628 | ENSDARP00000134625 | Actin alpha 1, skeletal muscle b. | Vascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | 0.811 |
acta1b | kras | ENSDARP00000058628 | ENSDARP00000147703 | Actin alpha 1, skeletal muscle b. | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. | 0.602 |
acta1b | lats1 | ENSDARP00000058628 | ENSDARP00000027561 | Actin alpha 1, skeletal muscle b. | LATS, large tumor suppressor, homolog 1 (Drosophila). | 0.481 |
acta1b | stat3 | ENSDARP00000058628 | ENSDARP00000095292 | Actin alpha 1, skeletal muscle b. | Signal transducer and activator of transcription. | 0.728 |
acta1b | tp53 | ENSDARP00000058628 | ENSDARP00000116736 | Actin alpha 1, skeletal muscle b. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.839 |
ccn1 | ccn2a | ENSDARP00000036965 | ENSDARP00000063027 | Cellular communication network factor 1. | Novel protein similar to vertebrate connective tissue growth factor (CTGF). | 0.718 |
ccn1 | cd44a | ENSDARP00000036965 | ENSDARP00000110970 | Cellular communication network factor 1. | CD44 molecule (Indian blood group) a. | 0.409 |
ccn1 | ctnnb1 | ENSDARP00000036965 | ENSDARP00000139205 | Cellular communication network factor 1. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.452 |
ccn1 | lats1 | ENSDARP00000036965 | ENSDARP00000027561 | Cellular communication network factor 1. | LATS, large tumor suppressor, homolog 1 (Drosophila). | 0.766 |
ccn1l2 | lats1 | ENSDARP00000141127 | ENSDARP00000027561 | Cellular communication network factor 1,-like 2. | LATS, large tumor suppressor, homolog 1 (Drosophila). | 0.739 |
ccn2a | acta1b | ENSDARP00000063027 | ENSDARP00000058628 | Novel protein similar to vertebrate connective tissue growth factor (CTGF). | Actin alpha 1, skeletal muscle b. | 0.654 |
ccn2a | ccn1 | ENSDARP00000063027 | ENSDARP00000036965 | Novel protein similar to vertebrate connective tissue growth factor (CTGF). | Cellular communication network factor 1. | 0.718 |
ccn2a | cd44a | ENSDARP00000063027 | ENSDARP00000110970 | Novel protein similar to vertebrate connective tissue growth factor (CTGF). | CD44 molecule (Indian blood group) a. | 0.437 |
ccn2a | cdh1 | ENSDARP00000063027 | ENSDARP00000136579 | Novel protein similar to vertebrate connective tissue growth factor (CTGF). | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | 0.566 |
ccn2a | ctnnb1 | ENSDARP00000063027 | ENSDARP00000139205 | Novel protein similar to vertebrate connective tissue growth factor (CTGF). | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.655 |
ccn2a | kdrl | ENSDARP00000063027 | ENSDARP00000134625 | Novel protein similar to vertebrate connective tissue growth factor (CTGF). | Vascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | 0.413 |