STRINGSTRING
zgc:110796 zgc:110796 ccn2a ccn2a kdrl kdrl cdh1 cdh1 ctnnb1 ctnnb1 ccn1l2 ccn1l2 csf3b csf3b acta1b acta1b tp53 tp53 tnc tnc cd44a cd44a stat3 stat3 msi1 msi1 ccn1 ccn1 csf3a csf3a lats1 lats1 il6 il6 kras kras cxcr2 cxcr2 pcna pcna
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
zgc:110796Zgc:110796. (94 aa)
ccn2aNovel protein similar to vertebrate connective tissue growth factor (CTGF). (345 aa)
kdrlVascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1301 aa)
cdh1Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
ccn1l2Cellular communication network factor 1,-like 2. (373 aa)
csf3bColony-stimulating factor 3 (granulocyte) b. (217 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
tncTenascin C. (1811 aa)
cd44aCD44 molecule (Indian blood group) a. (392 aa)
stat3Signal transducer and activator of transcription. (806 aa)
msi1Musashi RNA-binding protein 1. (297 aa)
ccn1Cellular communication network factor 1. (369 aa)
csf3aColony-stimulating factor 3 (granulocyte) a. (224 aa)
lats1LATS, large tumor suppressor, homolog 1 (Drosophila). (1068 aa)
il6Interleukin 6 (interferon, beta 2). (231 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
cxcr2Chemokine (C-X-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (340 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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