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ush2a ush2a Edn3 Edn3 slc26a4 slc26a4 lars2 lars2 ush1c ush1c atoh1a atoh1a ednrba ednrba chd7 chd7 edn3b edn3b clpp clpp eya1 eya1 cdh23-2 cdh23-2 six5 six5 ednrbb ednrbb ndp ndp col11a2 col11a2 col4a3 col4a3 col4a4 col4a4 cib2 cib2 foxi1 foxi1 pdzd7a pdzd7a adgrv1 adgrv1 cdh23 cdh23 clrn1 clrn1 myo7aa myo7aa ush1gb ush1gb six1b six1b pax3a pax3a snai2 snai2 col4a5 col4a5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ush2aUsher syndrome 2A (autosomal recessive, mild). (5236 aa)
Edn3END domain-containing protein. (102 aa)
slc26a4Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (760 aa)
lars2Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (835 aa)
ush1cUsher syndrome 1C (Autosomal recessive, severe). (548 aa)
atoh1aAtonal bHLH transcription factor 1a. (292 aa)
ednrbaEndothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (426 aa)
chd7Chromodomain helicase DNA-binding protein 7. (3140 aa)
edn3bEndothelin 3b. (153 aa)
clppATP-dependent Clp protease proteolytic subunit. (266 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (609 aa)
cdh23-2Cadherin-related 23. (436 aa)
six5SIX homeobox 5. (798 aa)
ednrbbEndothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (365 aa)
ndpNorrin cystine knot growth factor NDP. (138 aa)
col11a2Collagen, type XI, alpha 2. (1803 aa)
col4a3Collagen, type IV, alpha 3. (1684 aa)
col4a4Collagen, type IV, alpha 4. (1670 aa)
cib2Calcium and integrin-binding family member 2. (187 aa)
foxi1Forkhead box I1. (377 aa)
pdzd7aPDZ domain-containing 7a. (954 aa)
adgrv1Adhesion G-protein coupled receptor V1; Receptor that may have an important role in the development of the sensory nervous system. (6198 aa)
cdh23Cadherin-related 23. (2883 aa)
clrn1Clrn1 protein. (232 aa)
myo7aaMyosin VIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2190 aa)
ush1gbUsher syndrome 1Gb (autosomal recessive). (488 aa)
six1bHomeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa)
pax3aTranscription factor PAX3. (509 aa)
snai2Snail homolog 2 (Drosophila). (257 aa)
col4a5Collagen, type IV, alpha 5 (Alport syndrome). (1679 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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