STRINGSTRING
cish cish ncf2 ncf2 crfb4 crfb4 tgm2a tgm2a src src stat3 stat3 tdo2a tdo2a arg1 arg1 klf4 klf4 il10 il10 ifngr1 ifngr1 lectin lectin ifngr1l ifngr1l il13 il13 nos2a nos2a rac2 rac2 sp1 sp1 il4 il4 socs1b socs1b prom1a prom1a ptgs1 ptgs1 stat6 stat6 tnfa tnfa myd88 myd88 stat1a stat1a cyba cyba tnfb tnfb slc11a2 slc11a2 irf4a irf4a csf1ra csf1ra nos1 nos1 tdo2b tdo2b jak1 jak1 nos2b nos2b jak3 jak3 ncf1 ncf1 nr3c1 nr3c1 il10rb il10rb socs1a socs1a ido1 ido1 klf17 klf17 arg2 arg2 ncf4 ncf4 ch25h ch25h myb myb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cishCytokine inducible SH2-containing protein A. (212 aa)
ncf2Neutrophil cytosolic factor 2. (500 aa)
crfb4Cytokine receptor family member b4. (313 aa)
tgm2aTransglutaminase 2, C polypeptide A. (679 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
stat3Signal transducer and activator of transcription. (806 aa)
tdo2aTryptophan 2,3-dioxygenase A; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)
arg1Arginase. (341 aa)
klf4Kruppel-like factor 4. (340 aa)
il10Interleukin-10. (180 aa)
ifngr1Interferon gamma receptor 1. (394 aa)
lectinLectin. (152 aa)
ifngr1lInterferon gamma receptor 1-like. (385 aa)
il13Interleukin 4/13A. (157 aa)
nos2aNitric oxide synthase; Produces nitric oxide (NO). (1079 aa)
rac2Rac family small GTPase 2. (219 aa)
sp1Sp1 transcription factor. (594 aa)
il4Interleukin-4. (127 aa)
socs1bSuppressor of cytokine-signaling 1b. (193 aa)
prom1aProminin-1-A; May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. Involved in regulation of MAPK and Akt signaling pathways (By similarity); Belongs to the prominin family. (849 aa)
ptgs1Prostaglandin-endoperoxide synthase 1. (597 aa)
stat6Signal transducer and activator of transcription. (758 aa)
tnfaTumor necrosis factor a (TNF superfamily, member 2). (234 aa)
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. (284 aa)
stat1aSignal transducer and activator of transcription. (749 aa)
cybaCytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (185 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
slc11a2Solute carrier family 11 member 2. (231 aa)
irf4aInterferon regulatory factor 4a. (460 aa)
csf1raMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa)
tdo2bTryptophan 2,3-dioxygenase B; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (407 aa)
jak1Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures. (1153 aa)
nos2bNitric oxide synthase; Produces nitric oxide (NO). (1077 aa)
jak3Tyrosine-protein kinase. (1103 aa)
ncf1Neutrophil cytosolic factor 1. (410 aa)
nr3c1Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (746 aa)
il10rbInterleukin 10 receptor, beta. (367 aa)
socs1aSuppressor of cytokine-signaling 1a. (201 aa)
ido1Indoleamine 2,3-dioxygenase 1. (435 aa)
klf17Kruppel-like factor 17. (409 aa)
arg2Arginase. (347 aa)
ncf4Neutrophil cytosolic factor 4. (355 aa)
ch25hCholesterol 25-hydroxylase-like protein; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues: 25- hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol reg [...] (251 aa)
mybV-myb avian myeloblastosis viral oncogene homolog. (641 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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