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lmnb2 lmnb2 mcat mcat cfl1l cfl1l cfl2 cfl2 casp3a casp3a ctnnb1 ctnnb1 scinla scinla pax7a pax7a foxo1a foxo1a nrg1 nrg1 mcat-2 mcat-2 egfra egfra amot amot emd emd lats2 lats2 myf5 myf5 ttn.1 ttn.1 tead1a tead1a mtor mtor mstnb mstnb mef2ca mef2ca mob1ba mob1ba erbb4a erbb4a foxo1b foxo1b ptpn11a ptpn11a scinlb scinlb ptenb ptenb casp3b casp3b ccn2a ccn2a acta1b acta1b gsnb gsnb scin scin smad3a smad3a myf6 myf6 lats1 lats1 gsna gsna smad7 smad7 cfl1 cfl1 myog myog myod1 myod1 lmna lmna ptpn21 ptpn21 ccnd1 ccnd1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lmnb2Lamin B2; Belongs to the intermediate filament family. (583 aa)
mcatMalonyl CoA:ACP acyltransferase (mitochondrial). (364 aa)
cfl1lCofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. (163 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
scinlaScinderin-like a. (720 aa)
pax7aTranscription factor PAX7C. (507 aa)
foxo1aForkhead box protein O1-A; Transcriptional regulator of cell cycle arrest required for cellular stress responses (By similarity). May be involved in regulating cellular homeostasis in the eye. (652 aa)
nrg1Neuregulin 1. (730 aa)
mcat-2Malonyl CoA:ACP acyltransferase (mitochondrial). (231 aa)
egfraEpidermal growth factor receptor precursor. (625 aa)
amotAngiomotin. (1009 aa)
emdEmerin (Emery-Dreifuss muscular dystrophy). (182 aa)
lats2Large tumor suppressor kinase 2. (1140 aa)
myf5Myogenic factor. (237 aa)
ttn.1Titin, tandem duplicate 1. (29152 aa)
tead1aTEA domain family member 1a. (422 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
mstnbGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. May down-regulate muscle-specific transcription factors such as myod and myog. (374 aa)
mef2caMyocyte enhancer factor 2ca. (465 aa)
mob1baMOB1, Mps One Binder kinase activator-like 1A (Yeast). (216 aa)
erbb4aReceptor protein-tyrosine kinase. (1388 aa)
foxo1bForkhead box protein O1-B; Transcriptional regulator of cell cycle arrest required for cellular stress responses. (629 aa)
ptpn11aTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
scinlbScinderin-like b. (720 aa)
ptenbPhosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
ccn2aNovel protein similar to vertebrate connective tissue growth factor (CTGF). (345 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
gsnbGelsolin b. (728 aa)
scinScinderin. (733 aa)
smad3aMothers against decapentaplegic homolog. (425 aa)
myf6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (239 aa)
lats1LATS, large tumor suppressor, homolog 1 (Drosophila). (1068 aa)
gsnaGelsolin a. (729 aa)
smad7Mothers against decapentaplegic homolog. (372 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
myogMyogenin. (256 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
lmnaLamin A; Belongs to the intermediate filament family. (675 aa)
ptpn21Protein tyrosine phosphatase non-receptor type 21. (1204 aa)
ccnd1G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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