(72 nodes) (2016) Risk factors and biomarkers of age-related macular degeneration. network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	c4b	Complement 4B (Chido blood group). (1725 aa)
	c1s	Complement component 1, s subcomponent. (375 aa)
	b3glcta	Beta-3-glucosyltransferase a. (496 aa)
	c1r	Complement component 1, r subcomponent; Belongs to the peptidase S1 family. (662 aa)
	kdrl	Vascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1301 aa)
	rab27a	RAB27A, member RAS oncogene family. (222 aa)
	exoc3l2b	Exocyst complex component 3-like 2b. (861 aa)
	slc16a8	Solute carrier family 16 member 8. (453 aa)
	rab27b	RAB27B, member RAS oncogene family. (224 aa)
	ddx10	RNA helicase. (864 aa)
	il23r	Interleukin 23 receptor. (817 aa)
	flnb	Filamin B, beta (actin-binding protein 278). (2233 aa)
	hspa9	Heat shock protein 9; Belongs to the heat shock protein 70 family. (682 aa)
	hif1ab	Hypoxia-inducible factor 1 subunit alpha b. (777 aa)
	hmcn1	Hemicentin 1. (5616 aa)
	anxa5b	Annexin. (317 aa)
	myo7ab	Myosin VIIAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2190 aa)
	flncb	Filamin C, gamma b (actin-binding protein 280). (2773 aa)
	tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
	anxa5a	Annexin. (316 aa)
	frk	Tyrosine-protein kinase. (512 aa)
	hbl4	Hexose-binding lectin 4. (245 aa)
	hif1aa	Hypoxia-inducible factor 1 subunit alpha a. (717 aa)
	flnca	Filamin C, gamma a (actin-binding protein 280). (2719 aa)
	cetp	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (493 aa)
	ddx18	RNA helicase. (653 aa)
	kdr	Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1357 aa)
	cd36	CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (465 aa)
	rad51b	RAD51 paralog B. (373 aa)
	fbln5	Fibulin 5. (477 aa)
	acta1b	Actin alpha 1, skeletal muscle b. (377 aa)
	apoeb	Apolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. (281 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
	tgfb1a	Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
	ccl38a.5	C-C motif chemokine. (103 aa)
	igfbp2a	Insulin-like growth factor-binding protein 2-A; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (276 aa)
	egf	Epidermal growth factor. (1114 aa)
	cryaa	Crystallin, alpha A; Belongs to the small heat shock protein (HSP20) family. (173 aa)
	LOC563933	Serine protease; Belongs to the peptidase S1B family. (374 aa)
	EFEMP1	EGF containing fibulin extracellular matrix protein 1. (269 aa)
	timp2a	Tissue inhibitor of metalloproteinase 2. (220 aa)
	col15a1b	Collagen, type XV, alpha 1b. (1245 aa)
	col10a1a	Collagen, type X, alpha 1a. (655 aa)
	hspa8	Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] (649 aa)
	col8a1a	Collagen, type VIII, alpha 1a. (711 aa)
	mapk3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
	stat3	Signal transducer and activator of transcription. (806 aa)
	tgfb5	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	fscn2b	Fascin. (490 aa)
	hmcn2	Hemicentin 2. (4212 aa)
	c3a.2	Complement component c3a, duplicate 2. (1656 aa)
	hbl1	Zmp:0000000729. (254 aa)
	tgfbr1a	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (500 aa)
	flna	Filamin A, alpha (actin-binding protein 280). (2553 aa)
	ercc2	Excision repair cross-complementation group 2. (760 aa)
	tgfb1b	Transforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
	serping1	Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family. (604 aa)
	adamts9	ADAM metallopeptidase with thrombospondin type 1 motif, 9. (1461 aa)
	ercc6	Excision repair cross-complementation group 6. (1389 aa)
	ddx31	RNA helicase. (739 aa)
	timp4.3	TIMP metallopeptidase inhibitor 4, tandem duplicate 3. (198 aa)
	ddr1	Discoidin domain receptor tyrosine kinase 1. (974 aa)
	timp4.1	TIMP metallopeptidase inhibitor 4, tandem duplicate 1. (229 aa)
	Flnb	Uncharacterized protein. (157 aa)
	myo7aa	Myosin VIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2190 aa)
	ccr2	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	ccr2-2	Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	fadd	Fas (tnfrsf6)-associated via death domain. (192 aa)
	igfbp7	Insulin-like growth factor-binding protein 7. (257 aa)
	polr2b	Polymerase (RNA) II (DNA directed) polypeptide B; Belongs to the RNA polymerase beta chain family. (366 aa)
	noa1	Nitric oxide-associated 1. (702 aa)
	LOC101884302	Filamin A-interacting protein 1a. (1160 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EFEMP1	col8a1a	ENSDARP00000076579	ENSDARP00000093755	EGF containing fibulin extracellular matrix protein 1.	Collagen, type VIII, alpha 1a.	0.426
Flnb	acta1b	ENSDARP00000146236	ENSDARP00000058628	Uncharacterized protein.	Actin alpha 1, skeletal muscle b.	0.919
Flnb	fscn2b	ENSDARP00000146236	ENSDARP00000098380	Uncharacterized protein.	Fascin.	0.747
LOC101884302	flna	ENSDARP00000135896	ENSDARP00000113808	Filamin A-interacting protein 1a.	Filamin A, alpha (actin-binding protein 280).	0.432
LOC101884302	flnb	ENSDARP00000135896	ENSDARP00000114366	Filamin A-interacting protein 1a.	Filamin B, beta (actin-binding protein 278).	0.453
LOC101884302	flnca	ENSDARP00000135896	ENSDARP00000046217	Filamin A-interacting protein 1a.	Filamin C, gamma a (actin-binding protein 280).	0.490
LOC101884302	flncb	ENSDARP00000135896	ENSDARP00000024947	Filamin A-interacting protein 1a.	Filamin C, gamma b (actin-binding protein 280).	0.491
LOC563933	c3a.2	ENSDARP00000072648	ENSDARP00000108724	Serine protease; Belongs to the peptidase S1B family.	Complement component c3a, duplicate 2.	0.705
LOC563933	c4b	ENSDARP00000072648	ENSDARP00000115743	Serine protease; Belongs to the peptidase S1B family.	Complement 4B (Chido blood group).	0.421
LOC563933	hbl1	ENSDARP00000072648	ENSDARP00000110218	Serine protease; Belongs to the peptidase S1B family.	Zmp:0000000729.	0.541
LOC563933	hbl4	ENSDARP00000072648	ENSDARP00000037076	Serine protease; Belongs to the peptidase S1B family.	Hexose-binding lectin 4.	0.567
acta1b	Flnb	ENSDARP00000058628	ENSDARP00000146236	Actin alpha 1, skeletal muscle b.	Uncharacterized protein.	0.919
acta1b	anxa5a	ENSDARP00000058628	ENSDARP00000033328	Actin alpha 1, skeletal muscle b.	Annexin.	0.820
acta1b	anxa5b	ENSDARP00000058628	ENSDARP00000006207	Actin alpha 1, skeletal muscle b.	Annexin.	0.836
acta1b	apoeb	ENSDARP00000058628	ENSDARP00000058964	Actin alpha 1, skeletal muscle b.	Apolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family.	0.577
acta1b	ccl38a.5	ENSDARP00000058628	ENSDARP00000061310	Actin alpha 1, skeletal muscle b.	C-C motif chemokine.	0.490
acta1b	cd36	ENSDARP00000058628	ENSDARP00000050752	Actin alpha 1, skeletal muscle b.	CD36 molecule (thrombospondin receptor); Belongs to the CD36 family.	0.468
acta1b	egf	ENSDARP00000058628	ENSDARP00000069126	Actin alpha 1, skeletal muscle b.	Epidermal growth factor.	0.840
acta1b	flna	ENSDARP00000058628	ENSDARP00000113808	Actin alpha 1, skeletal muscle b.	Filamin A, alpha (actin-binding protein 280).	0.874
acta1b	flnb	ENSDARP00000058628	ENSDARP00000114366	Actin alpha 1, skeletal muscle b.	Filamin B, beta (actin-binding protein 278).	0.928

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