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alms1 alms1 cdh23 cdh23 ift88 ift88 acta1b acta1b mut mut wdr35 wdr35 arl13b arl13b DYNC2H1 DYNC2H1 ush1c ush1c grna grna pvalb7 pvalb7 cep290 cep290 pcdh15a pcdh15a pcdh15b pcdh15b cc2d2a cc2d2a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
alms1ALMS1 centrosome and basal body-associated protein. (2105 aa)
cdh23Cadherin-related 23. (2883 aa)
ift88Intraflagellar transport 88 homolog. (824 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
mutMethylmalonyl CoA mutase. (757 aa)
wdr35WD repeat-containing protein 35. (1203 aa)
arl13bADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] (407 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4208 aa)
ush1cUsher syndrome 1C (Autosomal recessive, severe). (548 aa)
grnaGranulin a. (1049 aa)
pvalb7Parvalbumin-7; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). (109 aa)
cep290Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and photot [...] (2439 aa)
pcdh15aProtocadherin-related 15a. (1796 aa)
pcdh15bProtocadherin-related 15b. (1907 aa)
cc2d2aCoiled-coil and C2 domain-containing 2A. (1675 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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