STRINGSTRING
lcp1 lcp1 npas4l npas4l ripply1 ripply1 cdx4 cdx4 spi1a spi1a twist2 twist2 cdh5 cdh5 myhc4 myhc4 myhz2 myhz2 runx1 runx1 hbae3 hbae3 pax5 pax5 lmo2 lmo2 tnnt2d tnnt2d actc1b actc1b tpm2 tpm2 flt4 flt4 tnnt2e tnnt2e kdrl kdrl myl10 myl10 fcer1g fcer1g smyhc3 smyhc3 smyhc1 smyhc1 eef1a1l1 eef1a1l1 gata1a gata1a flt1 flt1 myl1 myl1 twist3 twist3 rbfox1l rbfox1l pax1a pax1a trim33 trim33 tnnc1a tnnc1a spi1b spi1b ckma ckma twist1a twist1a etv2 etv2 twist1b twist1b tnnc1b tnnc1b nkx3-2 nkx3-2 acta1b acta1b myb myb pax9 pax9 fli1a fli1a foxc1b foxc1b tal1 tal1 efnb2b efnb2b tnnc2 tnnc2 ptprc ptprc
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lcp1Plastin-2; Actin-binding protein. Plays a role in the activation of T- cells (By similarity). (624 aa)
npas4lNeuronal PAS domain-containing protein 4-like; Transcription factor specifically expressed in endothelial and hematopoietic precursor cells that acts as a key regulator of the endothelial differentiation cascade. Acts as an early-response transcription factor that regulates the expression of early regulators of endothelial and haematopoietic differentiation, such as etv2 and tal1. (658 aa)
ripply1Protein ripply1; Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites. (140 aa)
cdx4Caudal type homeo box transcription factor 4. (270 aa)
spi1aSpi-1 proto-oncogene a. (257 aa)
twist2Twist2. (163 aa)
cdh5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (767 aa)
myhc4Myosin heavy chain 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
myhz2Myosin, heavy polypeptide 2, fast muscle-specific; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
runx1Runt-related transcription factor. (451 aa)
hbae3Hemoglobin alpha embryonic-3; Belongs to the globin family. (172 aa)
pax5Paired box 5. (396 aa)
lmo2Rhombotin-2; Transcription factor that acts synergistically with tal1/scl in primitive and definitive hematopoiesis, and in endothelial development. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hematopoietic induction cues such as gata1, tal1/scl-lmo2-induced haemangioblasts differentiate into endothelial cells. (159 aa)
tnnt2dTroponin T2d, cardiac. (241 aa)
actc1bActin, alpha 1, skeletal muscle. (377 aa)
tpm2Tropomyosin 2 (beta); Belongs to the tropomyosin family. (284 aa)
flt4Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. (1368 aa)
tnnt2eNovel slow skeletal troponin T family protein. (285 aa)
kdrlVascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1301 aa)
myl10Myosin, light chain 10, regulatory. (167 aa)
fcer1gFc fragment of IgE, high affinity I, receptor for; gamma polypeptide. (95 aa)
smyhc3Slow myosin heavy chain 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
smyhc1Slow myosin heavy chain 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
eef1a1l1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (462 aa)
gata1aGATA-binding protein 1a. (418 aa)
flt1Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1272 aa)
myl1Myosin, light chain 1, alkali; skeletal, fast; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. (190 aa)
twist3Twist3. (199 aa)
rbfox1lRNA binding protein fox-1 homolog 1-like; RNA-binding protein that regulates alternative splicing events by binding to 5'-GCAUG-3' elements. Regulates alternative splicing of tissue-specific exons. (382 aa)
pax1aPaired box 1a. (359 aa)
trim33E3 ubiquitin-protein ligase TRIM33; May act as an E3 ubiquitin-protein ligase and a transcriptional repressor (By similarity). Involved in the regulation of embryonic and adult hematopoiesis. Required for normal development and survival of both committed erythroid progenitor cells and posterior mesenchymal cells. (1176 aa)
tnnc1aTroponin C type 1a (slow). (161 aa)
spi1bSI:bY184L24.2.1 (Transcription factor spi1). (296 aa)
ckmaCreatine kinase, muscle a; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
twist1aTwist family bHLH transcription factor 1a. (171 aa)
etv2ETS variant transcription factor 2. (366 aa)
twist1bTwist family bHLH transcription factor 1b. (169 aa)
tnnc1bTroponin C type 1b (slow). (161 aa)
nkx3-2Bagpipe homeobox transcription factor Bapx1. (245 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
mybV-myb avian myeloblastosis viral oncogene homolog. (641 aa)
pax9Paired box 9. (343 aa)
fli1aFli-1 proto-oncogene, ETS transcription factor a. (451 aa)
foxc1bForkhead box C1-B; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1- mediated signals. Involved in epithelia [...] (433 aa)
tal1T-cell acute lymphocytic leukemia protein 1 homolog; Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the reg [...] (324 aa)
efnb2bEphrin-B2b; Belongs to the ephrin family. (334 aa)
tnnc2Fast skeletal muscle troponin C. (160 aa)
ptprcProtein tyrosine phosphatase receptor type C. (1130 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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