node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aars2 | dtd1 | ENSDARP00000113382 | ENSDARP00000065565 | Alanyl-tRNA synthetase 2, mitochondrial (putative). | D-aminoacyl-tRNA deacylase 1; D-aminoacyl-tRNA deacylase, with no observable activity on tRNAs charged with their cognate L-amino acid (By similarity). Hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly). Deacylates mischarged D.melanogaster and E.coli glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site (By similarity). By recycling D-aminoacyl-tRNA to D- amino acids and free tRNA molecules, this enzyme counteracts the toxicity a [...] | 0.619 |
aars2 | lars2 | ENSDARP00000113382 | ENSDARP00000099569 | Alanyl-tRNA synthetase 2, mitochondrial (putative). | Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.923 |
aars2 | wars | ENSDARP00000113382 | ENSDARP00000136378 | Alanyl-tRNA synthetase 2, mitochondrial (putative). | Tryptophanyl-tRNA synthetase. | 0.689 |
aars2 | wars2 | ENSDARP00000113382 | ENSDARP00000010571 | Alanyl-tRNA synthetase 2, mitochondrial (putative). | Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.845 |
acta1b | ctss1 | ENSDARP00000058628 | ENSDARP00000053637 | Actin alpha 1, skeletal muscle b. | Cathepsin S, ortholog 1; Belongs to the peptidase C1 family. | 0.464 |
acta1b | ctss2.1 | ENSDARP00000058628 | ENSDARP00000099159 | Actin alpha 1, skeletal muscle b. | Cathepsin S, ortholog2, tandem duplicate 1; Belongs to the peptidase C1 family. | 0.464 |
acta1b | ctss2.2 | ENSDARP00000058628 | ENSDARP00000034094 | Actin alpha 1, skeletal muscle b. | Cathepsin S, ortholog 2, tandem duplicate 2; Belongs to the peptidase C1 family. | 0.455 |
acta1b | flt4 | ENSDARP00000058628 | ENSDARP00000133227 | Actin alpha 1, skeletal muscle b. | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | 0.528 |
acta1b | kdr | ENSDARP00000058628 | ENSDARP00000049203 | Actin alpha 1, skeletal muscle b. | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | 0.748 |
acta1b | kdrl | ENSDARP00000058628 | ENSDARP00000134625 | Actin alpha 1, skeletal muscle b. | Vascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | 0.811 |
acta1b | notch1a | ENSDARP00000058628 | ENSDARP00000137942 | Actin alpha 1, skeletal muscle b. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.876 |
acta1b | vegfc | ENSDARP00000058628 | ENSDARP00000092263 | Actin alpha 1, skeletal muscle b. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.541 |
ctss1 | acta1b | ENSDARP00000053637 | ENSDARP00000058628 | Cathepsin S, ortholog 1; Belongs to the peptidase C1 family. | Actin alpha 1, skeletal muscle b. | 0.464 |
ctss2.1 | acta1b | ENSDARP00000099159 | ENSDARP00000058628 | Cathepsin S, ortholog2, tandem duplicate 1; Belongs to the peptidase C1 family. | Actin alpha 1, skeletal muscle b. | 0.464 |
ctss2.2 | acta1b | ENSDARP00000034094 | ENSDARP00000058628 | Cathepsin S, ortholog 2, tandem duplicate 2; Belongs to the peptidase C1 family. | Actin alpha 1, skeletal muscle b. | 0.455 |
dtd1 | aars2 | ENSDARP00000065565 | ENSDARP00000113382 | D-aminoacyl-tRNA deacylase 1; D-aminoacyl-tRNA deacylase, with no observable activity on tRNAs charged with their cognate L-amino acid (By similarity). Hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly). Deacylates mischarged D.melanogaster and E.coli glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site (By similarity). By recycling D-aminoacyl-tRNA to D- amino acids and free tRNA molecules, this enzyme counteracts the toxicity a [...] | Alanyl-tRNA synthetase 2, mitochondrial (putative). | 0.619 |
dtd1 | lars2 | ENSDARP00000065565 | ENSDARP00000099569 | D-aminoacyl-tRNA deacylase 1; D-aminoacyl-tRNA deacylase, with no observable activity on tRNAs charged with their cognate L-amino acid (By similarity). Hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly). Deacylates mischarged D.melanogaster and E.coli glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site (By similarity). By recycling D-aminoacyl-tRNA to D- amino acids and free tRNA molecules, this enzyme counteracts the toxicity a [...] | Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.448 |
dtd1 | wars2 | ENSDARP00000065565 | ENSDARP00000010571 | D-aminoacyl-tRNA deacylase 1; D-aminoacyl-tRNA deacylase, with no observable activity on tRNAs charged with their cognate L-amino acid (By similarity). Hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly). Deacylates mischarged D.melanogaster and E.coli glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site (By similarity). By recycling D-aminoacyl-tRNA to D- amino acids and free tRNA molecules, this enzyme counteracts the toxicity a [...] | Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.628 |
flt4 | acta1b | ENSDARP00000133227 | ENSDARP00000058628 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | Actin alpha 1, skeletal muscle b. | 0.528 |
flt4 | kdr | ENSDARP00000133227 | ENSDARP00000049203 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | 0.477 |