STRINGSTRING
ctnnb1 ctnnb1 nr5a2 nr5a2 ccne1 ccne1 foxa3 foxa3 ptf1a ptf1a isl1 isl1 pdx1 pdx1 mycn mycn cpa5 cpa5 ins ins fabp10a fabp10a zgc:92590 zgc:92590 wnt2 wnt2 pou5f3 pou5f3 zgc:173552 zgc:173552 LOC560023 LOC560023 E7FCZ0_DANRE E7FCZ0_DANRE prox1a prox1a prss1 prss1 esr1 esr1 zgc:113983 zgc:113983 h3f3a-2 h3f3a-2 tfa tfa myca myca LOC103908930 LOC103908930 insb insb zgc:171509 zgc:171509 prss59.2 prss59.2 zgc:162611-2 zgc:162611-2 X1WC94_DANRE X1WC94_DANRE sox17 sox17 ccnd1 ccnd1 zmp:0000001088 zmp:0000001088 TCF4 TCF4 eef1a1l1 eef1a1l1 kras kras hist2h3ca1 hist2h3ca1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
nr5a2Nuclear receptor subfamily 5, group A, member 2. (517 aa)
ccne1G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily. (410 aa)
foxa3Forkhead box A3. (441 aa)
ptf1aPancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. (265 aa)
isl1Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa)
pdx1Pancreatic and duodenal homeobox 1. (246 aa)
mycnN-myc protein; May function as a transcription factor. (503 aa)
cpa5Carboxypeptidase A5. (419 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
fabp10aFatty acid-binding protein 10-A, liver basic; Binds hydrophobic ligands, such as cholate, in the cytoplasm. May be involved in intracellular lipid transport (By similarity). Binds one cholate per subunit. (126 aa)
zgc:92590Zgc:92590; Belongs to the peptidase S1 family. (247 aa)
wnt2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). (350 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
zgc:173552Histone H3; Belongs to the histone H3 family. (136 aa)
LOC560023Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (226 aa)
E7FCZ0_DANRESi:dkey-33m11.8; Belongs to the peptidase S1 family. (251 aa)
prox1aProspero homeobox 1a. (739 aa)
prss1Serine protease 1; Belongs to the peptidase S1 family. (247 aa)
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (569 aa)
zgc:113983Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
h3f3a-2Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
tfaSerotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (673 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
LOC103908930Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (243 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
zgc:171509Zgc:171509; Belongs to the peptidase S1 family. (242 aa)
prss59.2Serine protease 59, tandem duplicate 2; Belongs to the peptidase S1 family. (257 aa)
zgc:162611-2Si:dkey-108k21.24. (151 aa)
X1WC94_DANRESi:dkeyp-93a5.2; Belongs to the peptidase S1 family. (284 aa)
sox17SRY-box transcription factor 17. (413 aa)
ccnd1G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa)
zmp:0000001088Zmp:0000001088; Belongs to the peptidase S1 family. (263 aa)
TCF4Transcription factor 4. (536 aa)
eef1a1l1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (462 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
hist2h3ca1Histone H3; Belongs to the histone H3 family. (136 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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