STRINGSTRING
gpx4b gpx4b gpx1b gpx1b gpx8 gpx8 dnmt1 dnmt1 gclc gclc gpx1a gpx1a cycsb cycsb suv39h1a suv39h1a hmox1a hmox1a TXN TXN gsr gsr trdmt1 trdmt1 nos2b nos2b ins ins hdac1 hdac1 txnipa txnipa gpx3 gpx3 txn txn zgc:173552 zgc:173552 cybb cybb hist1h4l hist1h4l kdm1a kdm1a zgc:113983 zgc:113983 tfam tfam sirt1 sirt1 h3f3a-2 h3f3a-2 gpx4a gpx4a rac1a rac1a tet2 tet2 mafb mafb kmt5c kmt5c nos2a nos2a mafa mafa insb insb nrf1 nrf1 gpx7 gpx7 gpx9 gpx9 zgc:162611-2 zgc:162611-2 txnipb txnipb kdm5a kdm5a nos1 nos1 hist2h3ca1 hist2h3ca1 ENSDARP00000142481 ENSDARP00000142481 park7 park7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gpx4bGlutathione peroxidase; Belongs to the glutathione peroxidase family. (170 aa)
gpx1bGlutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
gpx8Probable glutathione peroxidase 8; Belongs to the glutathione peroxidase family. (210 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1500 aa)
gclcGlutamate-cysteine ligase, catalytic subunit. (631 aa)
gpx1aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (191 aa)
cycsbCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (104 aa)
suv39h1aHistone-lysine N-methyltransferase SUV39H1-A; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric [...] (411 aa)
hmox1aHeme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (272 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (108 aa)
gsrGlutathione reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (425 aa)
trdmt1tRNA aspartic acid methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (381 aa)
nos2bNitric oxide synthase; Produces nitric oxide (NO). (1077 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa)
txnipaThioredoxin-interacting protein a. (400 aa)
gpx3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (222 aa)
txnThioredoxin; Belongs to the thioredoxin family. (107 aa)
zgc:173552Histone H3; Belongs to the histone H3 family. (136 aa)
cybbCytochrome b-245, beta polypeptide (chronic granulomatous disease). (565 aa)
hist1h4lHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (833 aa)
zgc:113983Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
tfamTranscription factor A, mitochondrial. (277 aa)
sirt1Sirtuin 1. (710 aa)
h3f3a-2Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
gpx4aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
rac1aRas-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (192 aa)
tet2Tet methylcytosine dioxygenase 2. (1715 aa)
mafbTranscription factor Maf; Acts as a transcriptional activator or repressor. Belongs to the bZIP family. Maf subfamily. (327 aa)
kmt5cLysine methyltransferase 5C. (519 aa)
nos2aNitric oxide synthase; Produces nitric oxide (NO). (1079 aa)
mafaV-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a); Belongs to the bZIP family. (325 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
nrf1Nuclear respiratory factor 1; Probable transcription factor that is required for normal development of the outer retina. (504 aa)
gpx7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
gpx9Glutathione peroxidase; Belongs to the glutathione peroxidase family. (140 aa)
zgc:162611-2Si:dkey-108k21.24. (151 aa)
txnipbThioredoxin-interacting protein b. (379 aa)
kdm5aLysine (K)-specific demethylase 5A. (1137 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa)
hist2h3ca1Histone H3; Belongs to the histone H3 family. (136 aa)
ENSDARP00000142481Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)
park7Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] (189 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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