STRINGSTRING
cdh1 cdh1 notch1a notch1a sctr sctr jag1b jag1b tgfb3 tgfb3 onecut1 onecut1 foxl1 foxl1 shhb shhb cftr cftr tgfb1a tgfb1a aqp12 aqp12 egf egf bmp4 bmp4 nog3 nog3 nog1 nog1 wnt3a wnt3a tcf7l1a tcf7l1a tgfb5 tgfb5 loxa loxa nog2 nog2 notch2 notch2 jag1a jag1a tgfb1b tgfb1b shha shha gli1 gli1 axin2 axin2 fgf2 fgf2 aqp11 aqp11 rspo1 rspo1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdh1Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
sctrUncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (445 aa)
jag1bProtein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
onecut1One cut domain family member. (461 aa)
foxl1Forkhead transcription factor. (360 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
cftrCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1485 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
aqp12Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (276 aa)
egfEpidermal growth factor. (1114 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
nog3Noggin-3; May function as an inhibitor of bone morphogenetic proteins (BMP) signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and BMP2/4. Not involved in organizer function or early phases of dorsoventral pattern formation; Belongs to the noggin family. (223 aa)
nog1Noggin-1; Inhibitor of bone morphogenetic proteins (BMP) signaling. May play an important role in the dorsoventral patterning of the embryo; Belongs to the noggin family. (216 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
tcf7l1aTranscription factor 7-like 1-A; Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Required early in development for dorsal specific gene activation and during gastrulation for repression of dorsal-specific genes in the marginal zone. Required for head formation and forebrain specification. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Belongs to the TCF/LEF family. (560 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
loxaLysyl oxidase a. (408 aa)
nog2Noggin-2; Inhibitor of bone morphogenetic proteins (BMP) signaling; Belongs to the noggin family. (212 aa)
notch2Notch receptor 2. (2475 aa)
jag1aProtein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1253 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
gli1GLI family zinc finger 1. (1404 aa)
axin2Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos. (812 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
aqp11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (275 aa)
rspo1R-spondin-1; Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway (By similarity). Belongs to the R-spondin family. (261 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.