STRINGSTRING
nfatc1 nfatc1 sel1l sel1l ptf1a ptf1a pdx1 pdx1 cpa1 cpa1 rbpja rbpja onecut1 onecut1 her12 her12 dicer1 dicer1 klf17 klf17 acta1b acta1b egf egf cdkn1bb cdkn1bb ptenb ptenb kat2b kat2b rbpjb rbpjb yap1 yap1 pik3c3 pik3c3 numb numb mapk3 mapk3 stat3 stat3 klf4 klf4 smad4a smad4a bhlha15 bhlha15 brca2 brca2 nfatc4 nfatc4 onecut3a onecut3a egfra egfra adam17b adam17b rbpjl rbpjl numbl numbl akt1 akt1 cdh1 cdh1 gata6 gata6 notch1a notch1a nr5a2 nr5a2 adam10a adam10a kras kras
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nfatc1Nuclear factor of-activated T cells 1. (867 aa)
sel1lSEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (776 aa)
ptf1aPancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. (265 aa)
pdx1Pancreatic and duodenal homeobox 1. (246 aa)
cpa1Carboxypeptidase A1 (pancreatic). (418 aa)
rbpjaRecombination signal-binding protein for immunoglobulin kappa J region a. (496 aa)
onecut1One cut domain family member. (461 aa)
her12BHLH transcription factor. (155 aa)
dicer1Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] (1865 aa)
klf17Kruppel-like factor 17. (409 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
egfEpidermal growth factor. (1114 aa)
cdkn1bbCyclin-dependent kinase inhibitor 1b (P27, kip1). (179 aa)
ptenbPhosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa)
kat2bHistone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (By similarity). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (By similarity). Also acetylates non- histone proteins. Involved in heart and limb development by mediating acetylation of tbx5. Also acetylates spermidine (By similarity). Together with kat2a, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) ; Bel [...] (796 aa)
rbpjbRecombination signal-binding protein for immunoglobulin kappa J region b. (491 aa)
yap1Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin netwo [...] (442 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (878 aa)
numbNUMB endocytic adaptor protein. (680 aa)
mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
stat3Signal transducer and activator of transcription. (806 aa)
klf4Kruppel-like factor 4. (340 aa)
smad4aMothers against decapentaplegic homolog. (547 aa)
bhlha15Basic helix-loop-helix family, member a15. (184 aa)
brca2BRCA2 DNA repair-associated. (2874 aa)
nfatc4Nuclear factor of-activated T cells 4. (865 aa)
onecut3aOne cut homeobox 3a. (446 aa)
egfraEpidermal growth factor receptor precursor. (625 aa)
adam17bADAM metallopeptidase domain 17b. (843 aa)
rbpjlRecombination signal-binding protein for immunoglobulin kappa J region-like. (510 aa)
numblNUMB-like endocytic adaptor protein. (618 aa)
akt1Non-specific serine/threonine protein kinase. (247 aa)
cdh1Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa)
gata6GATA-binding protein 6. (501 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
nr5a2Nuclear receptor subfamily 5, group A, member 2. (517 aa)
adam10aADAM metallopeptidase domain 10a. (763 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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