(33 nodes) (2017) Novel transcriptome assembly and comparative toxicity pathway analysis in mahi-mahi (Coryphaena hippurus) embryos and larvae exposed to Deepwater Horizon oil. network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tnnt2a	Troponin T type 2a (cardiac). (282 aa)
	abca1a	ATP-binding cassette, sub-family A (ABC1), member 1A. (2268 aa)
	hmgcrb	3-hydroxy-3-methylglutaryl coenzyme A reductase. (844 aa)
	dhcr7	7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC). (478 aa)
	smyhc2-2	Slow myosin heavy chain 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (184 aa)
	cyp1a	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. (519 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (441 aa)
	fdft1	Farnesyl-diphosphate farnesyltransferase 1. (418 aa)
	fgfr4	Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] (923 aa)
	casq2	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (409 aa)
	myl4	Myosin, light chain 4, alkali; atrial, embryonic. (187 aa)
	kcnj11	Potassium inwardly-rectifying channel, subfamily J, member 11. (381 aa)
	atp2a1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1005 aa)
	myl7	Myosin, light polypeptide 7, regulatory. (172 aa)
	ahr1b	Aryl hydrocarbon receptor 1B. (940 aa)
	tbx5a	T-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa)
	pik3ip1	Phosphoinositide-3-kinase-interacting protein 1; Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity. (265 aa)
	cdc42	Cell division cycle 42. (191 aa)
	fdps	Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (356 aa)
	nog2	Noggin-2; Inhibitor of bone morphogenetic proteins (BMP) signaling; Belongs to the noggin family. (212 aa)
	cxcl14	Chemokine (C-X-C motif) ligand 14. (100 aa)
	myh6	Myosin, heavy chain 6, cardiac muscle, alpha; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1936 aa)
	myl6	Myosin, light chain 6, alkali, smooth muscle and non-muscle. (164 aa)
	abcg8	ATP-binding cassette, sub-family G (WHITE), member 8. (332 aa)
	myh7	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
	hmgcra	3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa)
	abcg1	ATP-binding cassette, sub-family G (WHITE), member 1. (673 aa)
	abcg5	ATP-binding cassette, sub-family G (WHITE), member 5. (652 aa)
	kcnq1.1	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (655 aa)
	nog1	Noggin-1; Inhibitor of bone morphogenetic proteins (BMP) signaling. May play an important role in the dorsoventral patterning of the embryo; Belongs to the noggin family. (216 aa)
	msmo1	Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family. (291 aa)
	nog3	Noggin-3; May function as an inhibitor of bone morphogenetic proteins (BMP) signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and BMP2/4. Not involved in organizer function or early phases of dorsoventral pattern formation; Belongs to the noggin family. (223 aa)
	bmp4	Bone morphogenetic protein 4. (400 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
abca1a	abcg1	ENSDARP00000132417	ENSDARP00000087241	ATP-binding cassette, sub-family A (ABC1), member 1A.	ATP-binding cassette, sub-family G (WHITE), member 1.	0.496
abca1a	abcg5	ENSDARP00000132417	ENSDARP00000086278	ATP-binding cassette, sub-family A (ABC1), member 1A.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.437
abca1a	dhcr7	ENSDARP00000132417	ENSDARP00000136120	ATP-binding cassette, sub-family A (ABC1), member 1A.	7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).	0.562
abca1a	hmgcra	ENSDARP00000132417	ENSDARP00000088231	ATP-binding cassette, sub-family A (ABC1), member 1A.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.604
abca1a	hmgcrb	ENSDARP00000132417	ENSDARP00000133184	ATP-binding cassette, sub-family A (ABC1), member 1A.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.590
abca1a	nr1h3	ENSDARP00000132417	ENSDARP00000139970	ATP-binding cassette, sub-family A (ABC1), member 1A.	Nuclear receptor subfamily 1, group H, member 3.	0.976
abcg1	abca1a	ENSDARP00000087241	ENSDARP00000132417	ATP-binding cassette, sub-family G (WHITE), member 1.	ATP-binding cassette, sub-family A (ABC1), member 1A.	0.496
abcg1	abcg5	ENSDARP00000087241	ENSDARP00000086278	ATP-binding cassette, sub-family G (WHITE), member 1.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.690
abcg1	hmgcra	ENSDARP00000087241	ENSDARP00000088231	ATP-binding cassette, sub-family G (WHITE), member 1.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.468
abcg1	hmgcrb	ENSDARP00000087241	ENSDARP00000133184	ATP-binding cassette, sub-family G (WHITE), member 1.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.459
abcg1	nr1h3	ENSDARP00000087241	ENSDARP00000139970	ATP-binding cassette, sub-family G (WHITE), member 1.	Nuclear receptor subfamily 1, group H, member 3.	0.868
abcg5	abca1a	ENSDARP00000086278	ENSDARP00000132417	ATP-binding cassette, sub-family G (WHITE), member 5.	ATP-binding cassette, sub-family A (ABC1), member 1A.	0.437
abcg5	abcg1	ENSDARP00000086278	ENSDARP00000087241	ATP-binding cassette, sub-family G (WHITE), member 5.	ATP-binding cassette, sub-family G (WHITE), member 1.	0.690
abcg5	abcg8	ENSDARP00000086278	ENSDARP00000102567	ATP-binding cassette, sub-family G (WHITE), member 5.	ATP-binding cassette, sub-family G (WHITE), member 8.	0.999
abcg5	dhcr7	ENSDARP00000086278	ENSDARP00000136120	ATP-binding cassette, sub-family G (WHITE), member 5.	7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).	0.570
abcg5	hmgcra	ENSDARP00000086278	ENSDARP00000088231	ATP-binding cassette, sub-family G (WHITE), member 5.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.618
abcg5	hmgcrb	ENSDARP00000086278	ENSDARP00000133184	ATP-binding cassette, sub-family G (WHITE), member 5.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.518
abcg5	nr1h3	ENSDARP00000086278	ENSDARP00000139970	ATP-binding cassette, sub-family G (WHITE), member 5.	Nuclear receptor subfamily 1, group H, member 3.	0.739
abcg8	abcg5	ENSDARP00000102567	ENSDARP00000086278	ATP-binding cassette, sub-family G (WHITE), member 8.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.999
abcg8	dhcr7	ENSDARP00000102567	ENSDARP00000136120	ATP-binding cassette, sub-family G (WHITE), member 8.	7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).	0.606

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