STRINGSTRING
actn3b actn3b tln2b tln2b ctsbb ctsbb il1b il1b tln2a tln2a rab27a rab27a tln1 tln1 sh3pxd2aa sh3pxd2aa grb2b grb2b tfr1b tfr1b tgfb1b tgfb1b hcls1 hcls1 tp53 tp53 vamp3 vamp3 loxa loxa sp7 sp7 vcla vcla vclb vclb tgfb5 tgfb5 src src actr2b actr2b tnfsf11 tnfsf11 timp2a timp2a cdk5 cdk5 ctsba ctsba actr2a actr2a mmp9 mmp9 tgfb1a tgfb1a acta1b acta1b wasb wasb cd63 cd63 tgfb3 tgfb3 zgc:101810 zgc:101810 cfl1 cfl1 wasa wasa cttn cttn cfl2 cfl2 cfl1l cfl1l
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
actn3bActinin alpha 3b. (898 aa)
tln2bTalin 2b. (1537 aa)
ctsbbCathepsin Bb; Belongs to the peptidase C1 family. (327 aa)
il1bInterleukin-1. (284 aa)
tln2aTalin 2a. (2543 aa)
rab27aRAB27A, member RAS oncogene family. (222 aa)
tln1Talin 1. (2544 aa)
sh3pxd2aaSH3 and PX domain-containing protein 2A; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation; Belongs to the SH3PXD2 family. (1085 aa)
grb2bGrowth factor receptor-bound protein 2b. (217 aa)
tfr1bTransferrin receptor 1b. (771 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
hcls1Hematopoietic cell-specific Lyn substrate 1. (548 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
vamp3Vesicle-associated membrane protein 3 (Cellubrevin). (102 aa)
loxaLysyl oxidase a. (408 aa)
sp7Sp7 transcription factor. (528 aa)
vclaVinculin a. (1131 aa)
vclbVinculin b. (987 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
actr2bActin-related protein 2-B; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa)
tnfsf11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (251 aa)
timp2aTissue inhibitor of metalloproteinase 2. (220 aa)
cdk5Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ctsbaCathepsin B, a; Belongs to the peptidase C1 family. (330 aa)
actr2aActin-related protein 2-A; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa)
mmp9Matrix metallopeptidase 9. (680 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
wasbWASP actin nucleation-promoting factor b. (479 aa)
cd63Tetraspanin. (237 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
zgc:101810Zgc:101810; Belongs to the actin family. (394 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
wasaWASP actin nucleation-promoting factor a. (630 aa)
cttnCortactin. (536 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
cfl1lCofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. (163 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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