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kif7 | Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. (1363 aa) | ||||
ptch1 | Protein patched homolog 1. (1475 aa) | ||||
gli2a | GLI family zinc finger 2a. (1439 aa) | ||||
DYNC2H1 | Dynein cytoplasmic 2 heavy chain 1. (4208 aa) | ||||
sufu | Suppressor of fused homolog. (485 aa) | ||||
talpid3 | Protein TALPID3; Required for ciliogenesis and sonic hedgehog/SHH signaling. Belongs to the TALPID3 family. (1548 aa) | ||||
shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) | ||||
ENSDARP00000125042 | Patched 1. (120 aa) | ||||
fat1a | FAT atypical cadherin 1a. (4611 aa) | ||||
fto | FTO alpha-ketoglutarate-dependent dioxygenase. (567 aa) | ||||
dvl1b | Dishevelled segment polarity protein 1b. (716 aa) | ||||
lgals3a | Galectin. (332 aa) | ||||
ihhb | Indian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa) | ||||
ihha | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa) | ||||
wdr34 | WD repeat domain 34. (501 aa) | ||||
ptch2 | Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa) |