STRINGSTRING
myog myog jag1b jag1b myod1 myod1 jdp2b jdp2b ptch1 ptch1 gapdhs gapdhs snai2 snai2 gli3 gli3 gapdh gapdh pou5f3 pou5f3 dkk1b dkk1b rag2 rag2 notch3 notch3 mylpfa mylpfa ptch2 ptch2 mef2ca mef2ca hey1 hey1 sox2 sox2 mbtps2 mbtps2 nanog nanog lmnb1 lmnb1 myf5 myf5 snai1a snai1a runx1 runx1 jag1a jag1a met met myh9a myh9a ENSDARP00000125042 ENSDARP00000125042 gli1 gli1 actc1b actc1b pxdn pxdn axin2 axin2 notch1a notch1a pax7a pax7a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
myogMyogenin. (256 aa)
jag1bProtein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
jdp2bJun dimerization protein 2; Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins; Belongs to the bZIP family. ATF subfamily. (156 aa)
ptch1Protein patched homolog 1. (1475 aa)
gapdhsGlyceraldehyde-3-phosphate dehydrogenase 2; Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. (335 aa)
snai2Snail homolog 2 (Drosophila). (257 aa)
gli3GLI family zinc finger 3. (1553 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
dkk1bDickkopf WNT-signaling pathway inhibitor 1b. (241 aa)
rag2V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (530 aa)
notch3Notch receptor 3. (2468 aa)
mylpfaMyosin light chain, phosphorylatable, fast skeletal muscle a. (169 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
mef2caMyocyte enhancer factor 2ca. (465 aa)
hey1Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. (317 aa)
sox2Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). (315 aa)
mbtps2Membrane-bound transcription factor peptidase, site 2. (494 aa)
nanogOvary-expressed homeobox protein. (384 aa)
lmnb1Lamin B1; Belongs to the intermediate filament family. (603 aa)
myf5Myogenic factor. (237 aa)
snai1aSnail family zinc finger 1a. (260 aa)
runx1Runt-related transcription factor. (451 aa)
jag1aProtein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1253 aa)
metMET proto-oncogene, receptor tyrosine kinase. (1382 aa)
myh9aMyosin, heavy chain 9a, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1964 aa)
ENSDARP00000125042Patched 1. (120 aa)
gli1GLI family zinc finger 1. (1404 aa)
actc1bActin, alpha 1, skeletal muscle. (377 aa)
pxdnPeroxidasin. (1460 aa)
axin2Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos. (812 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
pax7aTranscription factor PAX7C. (507 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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