STRINGSTRING
tbxta tbxta tgfb3 tgfb3 gata5 gata5 smad1 smad1 cxcl12a cxcl12a tgfb1a tgfb1a dusp4 dusp4 pou5f3 pou5f3 cxcl12b cxcl12b foxh1 foxh1 eve1 eve1 ndr1 ndr1 cxcr4a cxcr4a col8a1a col8a1a tgfb5 tgfb5 itga6a itga6a spns2 spns2 nanog nanog smad2 smad2 mixl1 mixl1 wnt8a wnt8a wnt8-2 wnt8-2 tgfb1b tgfb1b sox17 sox17 gata6 gata6 sox32 sox32 eomesa eomesa tbxtb tbxtb dmd dmd tbx16 tbx16 foxa3 foxa3 foxa2 foxa2 etv4 etv4 dlc dlc fgf8a fgf8a mxtx2 mxtx2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tbxtaT-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
gata5Transcription factor gata5. (383 aa)
smad1Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. (472 aa)
cxcl12aChemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
dusp4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
cxcl12bChemokine (C-X-C motif) ligand 12B (Stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (97 aa)
foxh1Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa)
eve1Even-skipped-like1. (224 aa)
ndr1Nodal-related 1. (392 aa)
cxcr4aChemokine (C-X-C motif) receptor 4a; Belongs to the G-protein coupled receptor 1 family. (360 aa)
col8a1aCollagen, type VIII, alpha 1a. (711 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
itga6aIntegrin, alpha 6a; Belongs to the integrin alpha chain family. (1092 aa)
spns2Protein spinster homolog 2; Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in regulating heart development. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration ; Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family. (105 aa)
nanogOvary-expressed homeobox protein. (384 aa)
smad2Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. (469 aa)
mixl1Mix paired-like homeobox. (327 aa)
wnt8aProtein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis; Belongs to the Wnt family. (387 aa)
wnt8-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
sox17SRY-box transcription factor 17. (413 aa)
gata6GATA-binding protein 6. (501 aa)
sox32SRY-box transcription factor 32. (307 aa)
eomesaT-box transcription factor eomesodermin. (661 aa)
tbxtbT-box transcription factor Tb. (427 aa)
dmdDystrophin. (594 aa)
tbx16T-box transcription factor 16. (470 aa)
foxa3Forkhead box A3. (441 aa)
foxa2Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. (409 aa)
etv4ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. (494 aa)
dlcDelta-like protein C; Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. (664 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
mxtx2Mix-type homeobox gene 2. (296 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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