STRINGSTRING
TMC1 TMC1 ighv1-1 ighv1-1 pcdh15a pcdh15a ctnnb1 ctnnb1 pcdh15b pcdh15b adgrv1 adgrv1 ENSDARP00000060652 ENSDARP00000060652 ush2a ush2a cdh2 cdh2 LOC100004499 LOC100004499 cdhr1a cdhr1a ush1c ush1c
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TMC1Transmembrane channel-like protein 1; Probable ion channel required for the normal function of hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery ; Belongs to the TMC family. (990 aa)
ighv1-1Immunoglobulin heavy variable 1-1. (116 aa)
pcdh15aProtocadherin-related 15a. (1796 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
pcdh15bProtocadherin-related 15b. (1907 aa)
adgrv1Adhesion G-protein coupled receptor V1; Receptor that may have an important role in the development of the sensory nervous system. (6198 aa)
ENSDARP00000060652Si:ch211-57i17.5. (199 aa)
ush2aUsher syndrome 2A (autosomal recessive, mild). (5236 aa)
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
LOC100004499Stereocilin. (1934 aa)
cdhr1aCadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. (857 aa)
ush1cUsher syndrome 1C (Autosomal recessive, severe). (548 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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