STRINGSTRING
bmp4 bmp4 szl szl fsta fsta bmp2b bmp2b furinb furinb furina furina fstb fstb bmp7a bmp7a smad1 smad1 chrd chrd tll1 tll1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bmp4Bone morphogenetic protein 4. (400 aa)
szlSzl protein. (282 aa)
fstaFollistatin-A; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh) (By similarity). Inhibits bmp-signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and bmp2/4. Not involved in organizer function or early phases of dorsoventral pattern formation. (324 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
furinbFurin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family. (823 aa)
furinaFurin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family. (806 aa)
fstbFollistatin 2. (344 aa)
bmp7aBone morphogenetic protein 7a. (432 aa)
smad1Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. (472 aa)
chrdChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa)
tll1Dorsal-ventral patterning tolloid-like protein 1; Required for patterning ventral tissues of the tail. May increase bone morphogenetic protein (BMP) activity at the end of gastrulation by proteolytic cleavage of chordin and release of BMP from inactive complexes. (1022 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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