STRINGSTRING
psen1 psen1 scinla scinla kras kras cdkn2a/b cdkn2a/b fgf21 fgf21 hdac4 hdac4 gata1a gata1a mmp2 mmp2 gsna gsna atf3 atf3 ifnphi1 ifnphi1 trib3 trib3 hmox1a hmox1a sparc sparc fosab fosab scin scin gsnb gsnb txnipa txnipa irs2a irs2a egr1 egr1 tlr2 tlr2 rhebl1 rhebl1 acta1b acta1b adipor1b adipor1b jun jun htt htt cryaa cryaa lepr lepr scinlb scinlb tnfsf11 tnfsf11 pdgfra pdgfra stat3 stat3 hdac5 hdac5 myca myca crtc2 crtc2 xbp1 xbp1 asns asns rheb rheb mafa mafa irs4a irs4a ulk1b ulk1b adipor1a adipor1a dgat2 dgat2 tp53 tp53 angptl3 angptl3 bcl2a bcl2a tnfaip3 tnfaip3 nlrp1 nlrp1 txnipb txnipb ryr3 ryr3 adipor2 adipor2 fgf2 fgf2 eif2ak2 eif2ak2 pax6a pax6a irs2b irs2b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psen1Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family. (456 aa)
scinlaScinderin-like a. (720 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
cdkn2a/bCyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (129 aa)
fgf21Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. (194 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa)
gata1aGATA-binding protein 1a. (418 aa)
mmp2Matrix metalloproteinase 2. (657 aa)
gsnaGelsolin a. (729 aa)
atf3Activating transcription factor 3. (202 aa)
ifnphi1Interferon phi 1. (185 aa)
trib3Tribbles pseudokinase 3. (348 aa)
hmox1aHeme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (272 aa)
sparcSecreted protein, acidic, cysteine-rich (osteonectin). (291 aa)
fosabV-fos FBJ murine osteosarcoma viral oncogene homolog Ab. (349 aa)
scinScinderin. (733 aa)
gsnbGelsolin b. (728 aa)
txnipaThioredoxin-interacting protein a. (400 aa)
irs2aInsulin receptor substrate 2a. (1032 aa)
egr1Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (511 aa)
tlr2Toll-like receptor 2. (788 aa)
rhebl1Ras homolog, mTORC1-binding-like 1. (184 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
adipor1bAdiponectin receptor 1b. (329 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
httHuntingtin. (3121 aa)
cryaaCrystallin, alpha A; Belongs to the small heat shock protein (HSP20) family. (173 aa)
leprLeptin receptor. (1065 aa)
scinlbScinderin-like b. (720 aa)
tnfsf11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (251 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa)
stat3Signal transducer and activator of transcription. (806 aa)
hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1128 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
crtc2CREB-regulated transcription coactivator 2. (759 aa)
xbp1Transcription factor Treb5. (263 aa)
asnsAsparagine synthetase [glutamine-hydrolyzing]. (560 aa)
rhebRas homolog, mTORC1-binding. (93 aa)
mafaV-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a); Belongs to the bZIP family. (325 aa)
irs4aInsulin receptor substrate 4a. (1051 aa)
ulk1bUnc-51-like autophagy-activating kinase 1. (1011 aa)
adipor1aAdiponectin receptor 1a. (375 aa)
dgat2Diacylglycerol O-acyltransferase 2; Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation (By similarity). (366 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
angptl3Angiopoietin-like 3. (466 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
tnfaip3Tumor necrosis factor, alpha-induced protein 3. (756 aa)
nlrp1NACHT, LRR and PYD domains-containing protein 1 homolog; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, which activates caspases caspa and caspb leading to processing and secretion of proinflammatory cytokines. Required for the sequential recruitment of pro-caspa and pro-caspb to the inflammasome, which promotes activation of the caspases and the caspa/b-catalyzed il1b maturation and secretion in the e [...] (1192 aa)
txnipbThioredoxin-interacting protein b. (379 aa)
ryr3Ryanodine receptor 3. (4987 aa)
adipor2Novel protein similar to vertebrate adiponectin receptor 2 (ADIPOR2). (358 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
eif2ak2Eukaryotic translation initiation factor 2-alpha kinase 2. (682 aa)
pax6aPaired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. (451 aa)
irs2bInsulin receptor substrate 2b. (1062 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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