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mmp13a-2 mmp13a-2 ihhb ihhb ptch2 ptch2 gli3 gli3 thraa thraa ptch1 ptch1 gli2a gli2a ctsk ctsk sox6 sox6 thrb thrb sox5 sox5 adamts5 adamts5 gli1 gli1 shha shha ENSDARP00000125042 ENSDARP00000125042 calcr calcr sp7 sp7 tnfsf11 tnfsf11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mmp13a-2Matrix metallopeptidase 13a. (475 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
gli3GLI family zinc finger 3. (1553 aa)
thraaThyroid hormone receptor alpha-A; High affinity receptor for triiodothyronine (By similarity). In the absence of thyroid hormone during late blastula stage development, acts as a transcriptional repressor. Whereas in the presence of thyroid hormone, can act as an activator of transcription. In addition, represses retinoic acid (RA)-signaling during blastula and gastrula stages of development; Belongs to the nuclear hormone receptor family. NR1 subfamily. (427 aa)
ptch1Protein patched homolog 1. (1475 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
ctskCathepsin K; Belongs to the peptidase C1 family. (333 aa)
sox6SRY-box transcription factor 6. (816 aa)
thrbThyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for the thyroid gland hormone triiodothyronine (T3). Transactivating activity is ligand-dependent, and is repressed in the absence of T3. (508 aa)
sox5SRY-box transcription factor 5. (759 aa)
adamts5Peptidase M12B domain-containing protein. (937 aa)
gli1GLI family zinc finger 1. (1404 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
ENSDARP00000125042Patched 1. (120 aa)
calcrCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (598 aa)
sp7Sp7 transcription factor. (528 aa)
tnfsf11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (251 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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