STRINGSTRING
mmp9 mmp9 dmd dmd rcc2 rcc2 mespaa mespaa spint1b spint1b smarcd1 smarcd1 myod1 myod1 myog myog prmt1 prmt1 mycb mycb dnmt1 dnmt1 carm1 carm1 mmp23bb mmp23bb igf1ra igf1ra mdkb mdkb psmd11b psmd11b ccna1 ccna1 smarca1 smarca1 unc45b unc45b ezh2 ezh2 cldnd cldnd smyd1a smyd1a six1b six1b ctrb1 ctrb1 myf6 myf6 igf1rb igf1rb atp6v1e1b atp6v1e1b hdac1 hdac1 mdka mdka ache ache uba1 uba1 cldn1 cldn1 obscna obscna lft2 lft2 hbbe2 hbbe2 mcm10 mcm10 prmt7 prmt7 ldb3a ldb3a ihha ihha ihhb ihhb nnr nnr prmt5 prmt5 ambra1a ambra1a dnmt3aa dnmt3aa per1a per1a cth1 cth1 popdc2 popdc2 suz12a suz12a hs6st3a hs6st3a itga6a itga6a tmod1 tmod1 col6a1 col6a1 ccl27b ccl27b cdh5 cdh5 hbbe1.2 hbbe1.2 mat2aa mat2aa smarca5 smarca5 ttn.1 ttn.1 myhz2 myhz2 fn1a fn1a tmod4 tmod4 mef2d mef2d prim2 prim2 mta2 mta2 cavin4a cavin4a lamb2 lamb2 gpx7 gpx7 clcf1 clcf1 rbm24b rbm24b mespbb mespbb uba7 uba7 mych mych ndrg4 ndrg4 lama2 lama2 sgcd sgcd igfbp3 igfbp3 tspan34 tspan34 top2a top2a postnb postnb smarca4a smarca4a acta2 acta2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mmp9Matrix metallopeptidase 9. (680 aa)
dmdDystrophin. (594 aa)
rcc2Protein RCC2 homolog; Multifunctional protein that may effect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Interferes with the activation of RAC1 by guanine nucleotide exchange factors. Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton [...] (495 aa)
mespaaMesp-related bHLH transcription factor mesp-a. (223 aa)
spint1bSerine peptidase inhibitor, Kunitz type 1 b. (499 aa)
smarcd1SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily d, member 1. (510 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
myogMyogenin. (256 aa)
prmt1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (348 aa)
mycbTranscriptional regulator Myc-B; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (396 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1500 aa)
carm1Histone-arginine methyltransferase CARM1; Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me) and activates transcription via chromatin remodeling; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (588 aa)
mmp23bbMatrix metallopeptidase 23bb. (377 aa)
igf1raTyrosine-protein kinase receptor. (1405 aa)
mdkbMidkine-related growth factor Mdk2. (147 aa)
psmd11b26S proteasome non-ATPase regulatory subunit 11B; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmd11b is required for proteasome assembly (By similarity). (422 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (391 aa)
smarca1SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 1. (1036 aa)
unc45bProtein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development. Is necessary for normal early lens development. (934 aa)
ezh2Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily. (760 aa)
cldndClaudin-like protein ZF-A89; Component of tight junction (TJ) strands; Belongs to the claudin family. (208 aa)
smyd1aSET and MYND domain-containing 1a. (465 aa)
six1bHomeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa)
ctrb1Chymotrypsinogen B1; Belongs to the peptidase S1 family. (263 aa)
myf6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (239 aa)
igf1rbTyrosine-protein kinase receptor. (1380 aa)
atp6v1e1bATPase H+-transporting V1 subunit E1b. (226 aa)
hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa)
mdkaMidkine-related growth factor Mdk1. (146 aa)
acheAcetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. (634 aa)
uba1Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (1058 aa)
cldn1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
obscnaObscurin, cytoskeletal calmodulin and titin-interacting RhoGEF a. (1992 aa)
lft2Left-right determination factor. (362 aa)
hbbe2Hemoglobin beta embryonic-2; Belongs to the globin family. (147 aa)
mcm10Protein MCM10 homolog; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity). (833 aa)
prmt7Protein arginine N-methyltransferase 7; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being [...] (683 aa)
ldb3aCypher/ZASP splice variant 1 gamma. (596 aa)
ihhaHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
nnrNanor. (175 aa)
prmt5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (631 aa)
ambra1aActivating molecule in beclin-1-regulated autophagy. (1315 aa)
dnmt3aaDNA (cytosine-5-)-methyltransferase 3 alpha a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (852 aa)
per1aPeriod circadian clock 1a. (1352 aa)
cth1Putative zinc finger protein. (319 aa)
popdc2Popeye domain-containing 2; Important for striated muscle differentiation and cardiac morphogenesis. Is also required for cardiac conduction system development, plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding. (370 aa)
suz12aPolycomb protein suz12-A; Polycomb group (PcG) protein. Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity). (657 aa)
hs6st3aHeparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (420 aa)
itga6aIntegrin, alpha 6a; Belongs to the integrin alpha chain family. (1092 aa)
tmod1Tropomodulin 1. (356 aa)
col6a1Collagen, type VI, alpha 1. (1007 aa)
ccl27bChemokine (C-C motif) ligand 27b. (91 aa)
cdh5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (767 aa)
hbbe1.2Hemoglobin beta embryonic-1.2. (147 aa)
mat2aaS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (395 aa)
smarca5SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 5. (1035 aa)
ttn.1Titin, tandem duplicate 1. (29152 aa)
myhz2Myosin, heavy polypeptide 2, fast muscle-specific; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
fn1aFibronectin 1a. (2480 aa)
tmod4Tropomodulin 4 (Muscle). (343 aa)
mef2dMyocyte enhancer factor 2d. (529 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (508 aa)
mta2Metastasis-associated 1 family, member 2. (631 aa)
cavin4aCaveolae-associated protein 4a; Induces rhoa activation and activates nppa transcription and myofibrillar organization through the rho/rock signaling pathway. Belongs to the CAVIN family. (364 aa)
lamb2Laminin, beta 2 (laminin S). (1782 aa)
gpx7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
clcf1Cardiotrophin-like cytokine factor 1. (380 aa)
rbm24bRNA-binding motif protein 24b. (245 aa)
mespbbMesoderm posterior bb. (244 aa)
uba7Ubiquitin-like modifier-activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (1016 aa)
mychTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (360 aa)
ndrg4NDRG family member 4. (352 aa)
lama2Laminin, alpha 2. (845 aa)
sgcdSarcoglycan, delta (dystrophin-associated glycoprotein). (292 aa)
igfbp3Insulin-like growth factor-binding protein 3. (292 aa)
tspan34Tetraspanin. (234 aa)
top2aDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1570 aa)
postnbPeriostin, osteoblast-specific factor b. (782 aa)
smarca4aSWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 4a. (1627 aa)
acta2Actin, alpha 2, smooth muscle, aorta. (377 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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