STRINGSTRING
rel rel foxp1b foxp1b mmp9 mmp9 s1pr1 s1pr1 tgfb1a tgfb1a kat2a kat2a foxp3b foxp3b vcam1b vcam1b hdac4 hdac4 prkacaa prkacaa itgam itgam apoea apoea hmgcrb hmgcrb rela rela cdc42 cdc42 relb relb thbd thbd tgfb1b tgfb1b il15 il15 tgfb5 tgfb5 rapgef3 rapgef3 hdac5 hdac5 mif mif rabif rabif mmp13a-2 mmp13a-2 cd40 cd40 apoeb apoeb klf17 klf17 pfkfb3 pfkfb3 tgfb3 tgfb3 prkacba prkacba rhoab rhoab chuk chuk cxcr5 cxcr5 prkacab prkacab myca myca hmgcra hmgcra kat2b kat2b foxp3a foxp3a prkacbb prkacbb serpine1 serpine1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
relV-rel avian reticuloendotheliosis viral oncogene homolog. (596 aa)
foxp1bForkhead box protein P1-B; Transcriptional repressor. (659 aa)
mmp9Matrix metallopeptidase 9. (680 aa)
s1pr1Sphingosine 1-phosphate receptor 1; G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. (362 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
kat2aHistone acetyltransferase KAT2A; Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (By similarity). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for [...] (819 aa)
foxp3bForkhead box P3b. (394 aa)
vcam1bVascular cell adhesion molecule 1b. (808 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa)
prkacaaProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa)
itgamIntegrin, alpha M (complement component 3 receptor 3 subunit); Belongs to the integrin alpha chain family. (780 aa)
apoeaApolipoprotein Ea. (269 aa)
hmgcrb3-hydroxy-3-methylglutaryl coenzyme A reductase. (844 aa)
relaV-rel avian reticuloendotheliosis viral oncogene homolog A. (455 aa)
cdc42Cell division cycle 42. (191 aa)
relbV-rel avian reticuloendotheliosis viral oncogene homolog B. (582 aa)
thbdThrombomodulin. (468 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
il15Interleukin; Belongs to the IL-15/IL-21 family. (193 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
rapgef3Rap guanine nucleotide exchange factor (GEF) 3. (867 aa)
hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1128 aa)
mifMacrophage migration inhibitory factor. (115 aa)
rabifRAB-interacting factor. (132 aa)
mmp13a-2Matrix metallopeptidase 13a. (475 aa)
cd40CD40 molecule, TNF receptor superfamily member 5. (286 aa)
apoebApolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. (281 aa)
klf17Kruppel-like factor 17. (409 aa)
pfkfb36-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3. (536 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
prkacbaProtein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
chukInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (758 aa)
cxcr5Chemokine (C-X-C motif) receptor 5; Belongs to the G-protein coupled receptor 1 family. (378 aa)
prkacabProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
hmgcra3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa)
kat2bHistone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (By similarity). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (By similarity). Also acetylates non- histone proteins. Involved in heart and limb development by mediating acetylation of tbx5. Also acetylates spermidine (By similarity). Together with kat2a, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) ; Bel [...] (796 aa)
foxp3aForkhead box protein. (419 aa)
prkacbbProtein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
serpine1Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (392 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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