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efna3b efna3b cd247 cd247 ntn2 ntn2 shha shha pou4f3 pou4f3 epha4a epha4a lhx2b lhx2b epha6 epha6 cdh6 cdh6 celsr3 celsr3 foxd2 foxd2 nrcama nrcama plxnd1 plxnd1 pou4f2 pou4f2 ephb1 ephb1 sema3c sema3c cd44a cd44a mecp2 mecp2 opn4a opn4a adcy1b adcy1b neurog3 neurog3 slit1a slit1a dlx2a dlx2a foxg1a foxg1a fezf2 fezf2 epha7 epha7 adcy1a adcy1a wnt3a wnt3a tenm3 tenm3 pax2a pax2a islr2 islr2 gsx2 gsx2 calb2a calb2a emx2 emx2 shhb shhb zic2b zic2b sema3e sema3e calb2b calb2b her12 her12 foxd1 foxd1 rfx3 rfx3 efna2a efna2a vax1 vax1 ntn1b ntn1b epha4b epha4b zic2a zic2a isl2a isl2a vldlr vldlr tbr1b tbr1b efna3a efna3a dlx1a dlx1a gbx2 gbx2 opn4.1 opn4.1 sema5ba sema5ba nkx2.2a nkx2.2a slit1b slit1b fzd1 fzd1 Reln Reln ebf1b ebf1b lrp8 lrp8 pax6a pax6a ntn1a ntn1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
efna3bEphrin-A3b; Belongs to the ephrin family. (219 aa)
cd247CD247 molecule. (120 aa)
ntn2Netrin 2. (609 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
pou4f3POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. May play a role in specifying terminally differentiated neuronal phenotypes. (331 aa)
epha4aEphrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] (995 aa)
lhx2bLIM homeobox 2b. (427 aa)
epha6Eph receptor A6. (1001 aa)
cdh6Cadherin 6; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)
celsr3Cadherin, EGF LAG seven-pass G-type receptor 3. (2065 aa)
foxd2Forkhead box D2. (369 aa)
nrcamaNeuronal cell adhesion molecule a. (1285 aa)
plxnd1Plexin D1. (398 aa)
pou4f2POU domain protein. (384 aa)
ephb1EPH receptor B1. (694 aa)
sema3cSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C. (713 aa)
cd44aCD44 molecule (Indian blood group) a. (392 aa)
mecp2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (524 aa)
opn4aMelanopsin-A; Photoreceptor implicated in non-image-forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity); Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (594 aa)
adcy1bAdenylate cyclase 1b; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (834 aa)
neurog3Neurog3 protein. (208 aa)
slit1aSlit homolog 1a (Drosophila). (1524 aa)
dlx2aHomeobox protein Dlx2a; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (274 aa)
foxg1aForkhead box G1a. (420 aa)
fezf2Fez family zinc finger protein 2; Transcription repressor. Component of the regulatory cascade that controls the development of dopaminergic (DA) and serotonergic (5HT) neurons. (438 aa)
epha7Eph receptor A7. (1016 aa)
adcy1aAdenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
tenm3Teneurin-3; Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion (By similarity). Required by retinal ganglion cells for acquisition of their correct morphological and functional connectivity, thereby playing a key role in the development of the visu [...] (189 aa)
pax2aPaired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa)
islr2Immunoglobulin superfamily-containing leucine-rich repeat 2. (712 aa)
gsx2GS homeobox 2. (242 aa)
calb2aCalbindin 2, like. (271 aa)
emx2Empty spiracles homeobox 2. (247 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
zic2bZIC family member 2 (Odd-paired homolog, Drosophila) B. (427 aa)
sema3eSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family. (768 aa)
calb2bCalbindin 2b. (269 aa)
her12BHLH transcription factor. (155 aa)
foxd1Forkhead box D1. (343 aa)
rfx3Transcription factor RFX3; Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development; Belongs to the RFX family. (765 aa)
efna2aEphrin-A2; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the epha2 receptor may play a role in bone remodeling thro [...] (195 aa)
vax1Ventral anterior homeobox 1; Transcription factor that is required for closure of the choroid fissure and together with Vax2 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. (317 aa)
ntn1bNetrin 1b. (602 aa)
epha4bEph receptor A4b. (976 aa)
zic2aZIC family member 2 (Odd-paired homolog, Drosophila), A. (445 aa)
isl2aInsulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons. (359 aa)
vldlrVery low density lipoprotein receptor. (866 aa)
tbr1bT-box brain transcription factor 1b. (676 aa)
efna3aEphrin-A3a; Belongs to the ephrin family. (220 aa)
dlx1aHomeobox protein Dlx1a. (252 aa)
gbx2Gastrulation brain homeo box 2. (342 aa)
opn4.1Melanopsin-like; Photoreceptor implicated in non-image-forming responses to light. (500 aa)
sema5baannotation not available (1101 aa)
nkx2.2aHomeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). (273 aa)
slit1bSlit homolog 1b (Drosophila). (1532 aa)
fzd1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa)
RelnReelin domain-containing protein. (259 aa)
ebf1bEBF transcription factor 1b. (603 aa)
lrp8Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor. (984 aa)
pax6aPaired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. (451 aa)
ntn1aNetrin-1a. (603 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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