STRINGSTRING
mtor mtor myod1 myod1 gli2a gli2a smo smo prkg1a prkg1a ptch1 ptch1 dhh dhh acta1b acta1b jun jun prkg2 prkg2 ptch2 ptch2 ihhb ihhb dyrk4 dyrk4 myca myca dyrk3 dyrk3 tp53 tp53 dyrk2 dyrk2 ENSDARP00000125042 ENSDARP00000125042 shha shha gli1 gli1 prkg1b prkg1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
prkg1acGMP-dependent protein kinase. (667 aa)
ptch1Protein patched homolog 1. (1475 aa)
dhhDesert hedgehog protein; Intercellular signal essential for a variety of patterning events during development; Belongs to the hedgehog family. (447 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
prkg2cGMP-dependent protein kinase. (768 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
dyrk4Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 4. (634 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
dyrk3Dual-specificity tyrosine phosphorylation-regulated kinase 3. (582 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
dyrk2Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 2. (587 aa)
ENSDARP00000125042Patched 1. (120 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
gli1GLI family zinc finger 1. (1404 aa)
prkg1bcGMP-dependent protein kinase. (684 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (20%) [HD]